Inherited and age-related retinal degeneration is the hallmark of a large group of
heterogeneous diseases and is the main cause of untreatable blindness today. Genetic …

Leber congenital amaurosis (LCA) and early-onset severe retinal dystrophy (EOSRD) are
both genetically and phenotypically heterogeneous, and characterised clinically by severe …

Leber congenital amaurosis (LCA) is the most severe retinal dystrophy causing blindness or
severe visual impairment before the age of 1 year. Linkage analysis, homozygosity mapping …

The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly
understood, a problem that is exacerbated by the enormous genetic heterogeneity of this …

Inherited retinopathies (IR) are common untreatable blinding conditions. Most of them are
inherited as monogenic disorders, due to mutations in genes expressed in retinal …

Nonsyndromic recessive retinal dystrophies cause severe visual impairment due to the
death of photoreceptor and retinal pigment epithelium cells. These diseases until recently …

Over the last decade, huge progress has been made in the understanding of the molecular
mechanisms underlying inherited retinal dystrophy (IRD), as well as in the development and …

The domestic chicken, Gallus gallus, serves as an excellent model for the study of a wide
range of ocular diseases and conditions. The purpose of this manuscript is to outline some …

The embryonic chick occupies a privileged place among animal models used in
developmental studies. Its rapid development and accessibility for visualization and …

Many currently incurable forms of blindness affecting the retina have a genetic etiology and
several others, such as those resulting from retinal vascular disturbances, respond to …