Epoxides: an underestimated lipid oxidation product
KM Schaich - Free Radical Research, 2024 - Taylor & Francis
Immense gains in understanding of mechanisms and effects of lipid oxidation have been
achieved in the nearly 90 years over which lipid oxidation has been an active research …
achieved in the nearly 90 years over which lipid oxidation has been an active research …
Cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases
J Atone, K Wagner, K Hashimoto… - Prostaglandins & Other …, 2020 - Elsevier
Cytochrome P450 (CYP) metabolism of arachidonic acid (ARA) produces epoxy fatty acids
(EpFAs) such as epoxyeicosatrienoic acids (EETs) that are known to exert protective effects …
(EpFAs) such as epoxyeicosatrienoic acids (EETs) that are known to exert protective effects …
Crystalline silica-induced proinflammatory eicosanoid storm in novel alveolar macrophage model quelled by docosahexaenoic acid supplementation
OK Favor, LD Rajasinghe, KA Wierenga… - Frontiers in …, 2023 - frontiersin.org
Introduction Phagocytosis of inhaled crystalline silica (cSiO2) particles by tissue-resident
alveolar macrophages (AMs) initiates generation of proinflammatory eicosanoids derived …
alveolar macrophages (AMs) initiates generation of proinflammatory eicosanoids derived …
Relative importance of soluble and microsomal epoxide hydrolases for the hydrolysis of epoxy-fatty acids in human tissues
Epoxy-fatty acids (EpFAs) are endogenous lipid mediators that have a large breadth of
biological activities, including the regulation of blood pressure, inflammation, angiogenesis …
biological activities, including the regulation of blood pressure, inflammation, angiogenesis …
Lipidome modulation by dietary omega-3 polyunsaturated fatty acid supplementation or selective soluble epoxide hydrolase inhibition suppresses rough LPS …
OK Favor, PS Chauhan, E Pourmand… - Frontiers in …, 2023 - frontiersin.org
Introduction Lipopolysaccharide (LPS)-accelerated autoimmune glomerulonephritis (GN) in
NZBWF1 mice is a preclinical model potentially applicable for investigating lipidome …
NZBWF1 mice is a preclinical model potentially applicable for investigating lipidome …
Advances in targeted liquid chromatography‐tandem mass spectrometry methods for endocannabinoid and N‐acylethanolamine quantification in biological matrices …
Liquid chromatography paired with tandem mass spectrometry (LC‐MS/MS) is the gold
standard in measurement of endocannabinoid concentrations in biomatrices. We conducted …
standard in measurement of endocannabinoid concentrations in biomatrices. We conducted …
Impact of soluble epoxide hydrolase inhibition on silica-induced pulmonary fibrosis, ectopic lymphoid neogenesis, and autoantibody production in lupus-prone mice
OF McDonald, JG Wagner, RP Lewandowski… - Inhalation …, 2024 - Taylor & Francis
Objective Acute intranasal (IN) instillation of lupus-prone NZBWF1 mice with crystalline silica
(cSiO2) triggers robust lung inflammation that drives autoimmunity. Prior studies in other …
(cSiO2) triggers robust lung inflammation that drives autoimmunity. Prior studies in other …
Prostaglandins and other lipid mediators cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases
J Atone, K Wagner, K Hashimoto… - Prostaglandins & other …, 2019 - pmc.ncbi.nlm.nih.gov
Cytochrome P450 (CYP) metabolism of arachidonic acid (ARA) produces epoxy fatty acids
(EpFAs) such as epoxyeicosatrienoic acids (EETs) that are known to exert protective effects …
(EpFAs) such as epoxyeicosatrienoic acids (EETs) that are known to exert protective effects …
Absolute protein assay for the simultaneous quantification of two epoxide hydrolases in rats by mass spectrometry–based targeted proteomics
T Wu, X Xi, Y Chen, C Jiang, Q Zhang… - Journal of …, 2021 - Wiley Online Library
Epoxide hydrolases catalyze the hydrolysis of both exogenous and endogenous epoxides to
the corresponding vicinal diols by adding water. Microsomal and soluble epoxide hydrolase …
the corresponding vicinal diols by adding water. Microsomal and soluble epoxide hydrolase …
[图书][B] Lipidome Modulation in Environmentally-Triggered Autoimmunity
OK Favor - 2023 - search.proquest.com
Autoimmune diseases are chronic, uncured, life-altering illnesses caused by immune cells
mistakenly attacking and damaging host tissues. While genetic predispositions play a vital …
mistakenly attacking and damaging host tissues. While genetic predispositions play a vital …