Transforming growth factor β (TGF-β) signaling pathway plays important roles in many
biological processes, including cell growth, differentiation, apoptosis, migration, as well as …

First described in 1991, Yin Yang 1 (YY1) is a transcription factor that is ubiquitously
expressed throughout mammalian cells. It regulates both transcriptional activation and …

The TGF-β family comprises many structurally related differentiation factors that act through
a heteromeric receptor complex at the cell surface and an intracellular signal transducing …

Bone morphogenetic proteins (BMPs), members of the transforming growth factor-β (TGF-β)
superfamily, bind to two different serine/threonine kinase receptors, and mediate their …

The ubiquitous transcription factor Yin Yang 1 (YY1) is known to have a fundamental role in
normal biologic processes such as embryogenesis, differentiation, replication, and cellular …

Yin Yang 1 (YY1), a dual function transcription factor, is known to regulate transcriptional
activation and repression of many genes associated with multiple cellular processes …

Epithelial-mesenchymal transition (EMT) contributes to normal tissue patterning and
carcinoma invasiveness. We show that transforming growth factor (TGF)-β/activin members …

Transforming growth factor-β (TGF-β) is a secreted polypeptide that signals via receptor
serine/threonine kinases and intracellular Smad effectors. TGF-β inhibits proliferation and …

BMP and Wnt signaling pathways control essential cellular responses through activation of
the transcription factors SMAD (BMP) and TCF (Wnt). Here, we show that regeneration of …

Transforming growth factor‐beta (TGF‐β) is an important growth inhibitor of epithelial cells,
and insensitivity to this cytokine results in uncontrolled cell proliferation and can contribute to …