Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy,
infection and transplantation, patient outcomes are linked to the degree of immune …

The timely reconstitution and regain of function of a donor-derived immune system is of
utmost importance for the recovery and long-term survival of patients after allogeneic …

The decrease of TCR diversity with aging has never been studied by direct methods. In this
study, we combined high-throughput Illumina sequencing with unique cDNA molecular …

Atopic dermatitis (AD) is a chronic, relapsing, highly pruritic skin condition resulting from
disruption of the epithelial barrier and associated immune dysregulation in the skin of …

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the most effective
treatment for selected patients with acute myeloid leukemia (AML) and relies on a “graft …

Infection is the leading cause of non-relapse mortality after allogeneic haematopoietic cell
transplantation (HCT). This occurs as a result of dysfunction to the host immune system from …

Cytoreductive conditioning regimens used in the context of allogeneic hematopoietic cell
transplantation (HCT) elicit deficits in innate and adaptive immunity, which predispose …

A major obstacle of allogeneic haematopoietic stem cell transplantation is graft-versus-host
disease, an immune-mediated disorder that affects multiple tissues and organs with varying …

Adoptive transfer of donor-derived T lymphocytes expressing a safety switch may promote
immune reconstitution in patients undergoing haploidentical hematopoietic stem cell …

Poor graft function (PGF), defined by the presence of multilineage cytopenias in the
presence of 100% donor chimerism, is a serious complication of allogeneic stem cell …