Stem cell-derived organoids are a promising tool to model native human tissues as they
resemble human organs functionally and structurally compared to traditional monolayer cell …

With advances in underlying technologies such as complex multicellular systems, synthetic
materials, and bioengineering techniques, we can now generate in vitro miniaturized human …

The morphogenetic events leading to tissue formation can be recapitulated using organoids,
which allows studying new diseases and modelling personalized medicines. In this review …

Abstract Three-dimensional (3D) organoid cultures are flexible systems to interrogate
cellular growth, morphology, multicellular spatial architecture, and cellular interactions in …

Contrary to 2D cells, 3D organoid structures are composed of diverse cell types and exhibit
morphologies of various sizes. Although researchers frequently monitor morphological …

Problem Organoids are 3D cultures that are commonly used for biological and medical
research in vitro due to their functional and structural similarity to source organs. The …

Abstract Objective Mitomycin C (MMC), a DNA-damaging chemotherapeutic, is commonly
used clinically for recurrent cervical carcinoma (CC), either alone or in combination. MMC …

Organoids offer a powerful model to study cellular self-organisation, the growth of specific
tissue morphologies in-vitro, and to assess potential medical therapies. However, the …

The process of annotating relevant data in the field of digital microscopy can be both time-
consuming and especially expensive due to the required technical skills and human-expert …

This study focuses on refining growth-rate-based drug response metrics for patient-derived
tumor organoid screening using brightfield live-cell imaging. Traditional metrics like …