Amorphous solid dispersions (ASDs) can increase the oral bioavailability of poorly soluble
drugs. However, their use in drug development is comparably rare due to a lack of basic …

Accurate prediction of the in vivo biopharmaceutical performance of oral drug formulations is
critical to efficient drug development. Traditionally, in vitro evaluation of oral drug …

Drug absorption from the gastrointestinal (GI) tract is a highly complex process dependent
upon numerous factors including the physicochemical properties of the drug, characteristics …

Supersaturating drug delivery systems (SDDS) hold the promise of enabling intestinal
absorption for difficult-to-formulate, poorly soluble drug candidates based on a design …

Lipid-based formulations (LBFs) have demonstrated a great potential in enhancing the oral
absorption of poorly water-soluble drugs. However, construction of in vitro and in vivo …

Introduction: Poor aqueous solubility of active pharmaceutical ingredients (APIs) is one of
the main challenges in the development of new small molecular drugs. Additionally, the …

Introduction: With the increasing number of poorly water-soluble compounds in drug
discovery pipelines, supersaturating drug delivery systems (SDDS) have attracted increased …

Purpose Recent studies have shown that digestion of lipid-based formulations (LBFs) can
stimulate both supersaturation and precipitation. The current study has evaluated the drug …

As numerous new drug candidates are poorly water soluble, enabling formulations are
needed to increase their bioavailability for oral administration. Nanoparticles are a …

Supersaturation is a promising strategy to improve gastrointestinal absorption of poorly
water-soluble drugs. Supersaturation is a metastable state and therefore dissolved drugs …