Topical gel-based biomaterials for the treatment of diabetic foot ulcers

JR Bardill, MR Laughter, M Stager, KW Liechty… - Acta biomaterialia, 2022 - Elsevier
Diabetic foot ulcers (DFUs) are a devastating ailment for many diabetic patients with
increasing prevalence and morbidity. The complex pathophysiology of DFU wound …

Electrospun nanofibrous materials for wound healing

Y Dong, Y Zheng, K Zhang, Y Yao, L Wang, X Li… - Advanced Fiber …, 2020 - Springer
Wound dressing materials which are capable of meeting the demands of accelerating
wound closure and promoting wound healing process have being highly desired …

Mesenchymal stem cell-derived extracellular vesicles: opportunities and challenges for clinical translation

M Maumus, P Rozier, J Boulestreau… - … in Bioengineering and …, 2020 - frontiersin.org
Extracellular vesicles (EVs), including exosomes and microvesicles, derived from
mesenchymal stem/stromal cells (MSCs) exert similar effects as their parental cells, and are …

Intranasal delivery of mesenchymal stem cell secretome repairs the brain of Alzheimer's mice

G Santamaria, E Brandi, PL Vitola, F Grandi… - Cell Death & …, 2021 - nature.com
The multiplicity of systems affected in Alzheimer's disease (AD) brains calls for multi-target
therapies. Although mesenchymal stem cells (MSC) are promising candidates, their clinical …

Characterizing the impact of 2D and 3D culture conditions on the therapeutic effects of human mesenchymal stem cell secretome on corneal wound healing in vitro …

K Carter, HJ Lee, KS Na, GM Fernandes-Cunha… - Acta biomaterialia, 2019 - Elsevier
The therapeutic effects of secreted factors (secretome) produced by bone marrow-derived
human mesenchymal stem cells (MSCs) were evaluated as a function of their growth in 2D …

Nanobiotechnology-assisted therapies to manage brain cancer in personalized manner

M Nehra, UT Uthappa, V Kumar, R Kumar… - Journal of Controlled …, 2021 - Elsevier
There are numerous investigated factors that limit brain cancer treatment efficacy such as
ability of prescribed therapy to cross the blood-brain barrier (BBB), tumor specific delivery of …

Bone marrow mesenchymal stem cell-derived exosomes attenuate D-GaIN/LPS-induced hepatocyte apoptosis by activating autophagy in vitro

S Zhao, Y Liu, Z Pu - Drug design, development and therapy, 2019 - Taylor & Francis
Background Acute liver failure is an inflammation-mediated hepatocyte injury. Mesenchymal
stem cell (MSC) transplantation is currently considered to be an effective treatment strategy …

Mesenchymal stem cell spheroids embedded in an injectable thermosensitive hydrogel: an in situ drug formation platform for accelerated wound healing

MA Nilforoushzadeh, M Khodadadi Yazdi… - ACS biomaterials …, 2020 - ACS Publications
The ability of mesenchymal stem cells (MSCs) to enhance cutaneous wound healing has
been well established. Extensive expansion of cells to reach sufficient cell numbers for …

Mesenchymal stem cell-based therapy for autoimmune diseases: emerging roles of extracellular vesicles

F Rad, M Ghorbani, A Mohammadi Roushandeh… - Molecular Biology …, 2019 - Springer
In autoimmune disease body's own immune system knows healthy cells as undesired and
foreign cells. Over 80 types of autoimmune diseases have been recognized. Currently, at …

Mesenchymal stromal cell-based therapy: new perspectives and challenges

M Najar, F Bouhtit, R Melki, H Afif, A Hamal… - Journal of clinical …, 2019 - mdpi.com
Stem cells have been the focus of intense research opening up new possibilities for the
treatment of various diseases. Mesenchymal stromal cells (MSCs) are multipotent cells with …