Chronic orofacial pain: models, mechanisms, and genetic and related environmental influences

BJ Sessle - International journal of molecular sciences, 2021 - mdpi.com
Chronic orofacial pain conditions can be particularly difficult to diagnose and treat because
of their complexity and limited understanding of the mechanisms underlying their aetiology …

NKCC1, an elusive molecular target in brain development: making sense of the existing data

MA Virtanen, P Uvarov, CA Hübner, K Kaila - Cells, 2020 - mdpi.com
Ionotropic GABA transmission is mediated by anion (mainly Cl−)-permeable GABAA
receptors (GABAARs). In immature neurons, GABA exerts depolarizing and sometimes …

The ups and downs of alkyl‐carbamates in epilepsy therapy: how does cenobamate differ?

W Löscher, GJ Sills, HS White - Epilepsia, 2021 - Wiley Online Library
Since 1955, several alkyl‐carbamates have been developed for the treatment of anxiety and
epilepsy, including meprobamate, flupirtine, felbamate, retigabine, carisbamate, and …

Inhibition of ferroptosis‐like cell death attenuates neuropathic pain reactions induced by peripheral nerve injury in rats

Y Guo, J Du, C Xiao, P Xiang, Y Deng… - European Journal of …, 2021 - Wiley Online Library
Background Relationships between iron‐dependent ferroptosis and nerve system diseases
have been recently revealed. However, the role of ferroptosis in neuropathic pain (NeP) …

The role and pharmacological properties of the P2X7 receptor in neuropathic pain

W Zhang, Z Zhu, Z Liu - Brain Research Bulletin, 2020 - Elsevier
Neuropathic Pain (NPP) is caused by direct or indirect damage to the nervous system and is
a common symptom of many diseases. Clinically, drugs are usually used to suppress pain …

Diagnosis and management of neuropathic pain in spine diseases

J Bielewicz, M Kamieniak, M Szymoniuk, J Litak… - Journal of Clinical …, 2023 - mdpi.com
Neuropathic pain is generally defined as a non-physiological pain experience caused by
damage to the nervous system. It can occur spontaneously, as a reaction to a given stimulus …

Wnt signaling: A prospective therapeutic target for chronic pain

YQ Zhou, XB Tian, YK Tian, W Mei, DQ Liu… - Pharmacology & …, 2022 - Elsevier
Despite the rapid advance over the past decades to design effective therapeutic
pharmacological interventions, chronic pain remains to be an unresolved healthcare …

Angiotensin receptors and neuropathic pain

M Balogh, C Aguilar, NT Nguyen, AJ Shepherd - Pain reports, 2021 - journals.lww.com
Growing evidence implicates the renin–angiotensin system (RAS) in multiple facets of
neuropathic pain (NP). This narrative review focuses primarily on the major bioactive RAS …

Exercise training modulates glutamic acid decarboxylase-65/67 expression through TrkB signaling to ameliorate neuropathic pain in rats with spinal cord injury

X Li, Q Wang, J Ding, S Wang, C Dong… - Molecular …, 2020 - journals.sagepub.com
Neuropathic pain is one of the most frequently stated complications after spinal cord injury.
In post-spinal cord injury, the decrease of gamma aminobutyric acid synthesis within the …

The role of P2X4 receptor in neuropathic pain and its pharmacological properties

WJ Zhang, ZM Zhu, ZX Liu - Pharmacological research, 2020 - Elsevier
Neuropathic pain (NPP) is a common symptom of most diseases in clinic, which seriously
affects the mental health of patients and brings certain pain to patients. Due to its …