The accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER
stress, resulting in activation of the unfolded protein response (UPR) that aims to restore …

The GBA gene encodes for the lysosomal enzyme glucocerebrosidase (GCase), which
maintains glycosphingolipid homeostasis. Approximately 5–15% of PD patients have …

Protein folding is inherently error prone, especially in the endoplasmic reticulum (ER). Even
with an elaborate network of molecular chaperones and protein folding facilitators …

The ubiquitin proteasome system maintains protein homeostasis by regulating the
breakdown of misfolded proteins, thereby preventing misfolded protein aggregates. The …

Autosomal recessive IRF7 and IRF9 deficiencies impair type I and III IFN immunity and
underlie severe influenza pneumonitis. We report three unrelated children with influenza A …

Endoplasmic reticulum (ER) stress may be both a trigger and consequence of chronic
inflammation. Chronic inflammation is often associated with diseases that arise because of …

Proteasome dysfunction can lead to autoinflammatory disease associated with elevated type
I interferon (IFN-αβ) and NF-κB signaling; however, the innate immune pathway driving this …

Loss-of-function diseases are often caused by destabilizing mutations that lead to protein
misfolding and degradation. Modulating the innate protein homeostasis (proteostasis) …

2-Hydroxypropyl-β-cyclodextrin (HPβCD) is a Food and Drug Administration-approved
excipient used to improve the stability and bioavailability of drugs. Despite its wide use as a …

Cerium oxide nanoparticles (nanoceria) are widely used in a variety of industrial
applications including UV filters and catalysts. The expanding commercial scale production …