An active targeting strategy-enabled DNA tetrahedron delivery vehicle could facilitate stable
drug encapsulation and stimuli-responsive on-demand release, building a universal …

The physicochemical nature of DNA allows the assembly of highly predictable structures via
several fabrication strategies, which have been applied to make breakthroughs in various …

MicroRNA (miR)‐based therapy shows strong potential; however, structural limitations pose
a challenge in fully exploiting its biomedical functionality. Tetrahedral framework DNA (tFNA) …

As microRNAs (miRNA) regulate almost all physiopathological activities in the human body,
miRNA therapeutics that deliver miRNA regulators have attracted considerable attention in …

RNA origami is a method for designing RNA nanostructures that can self-assemble through
co-transcriptional folding with applications in nanomedicine and synthetic biology. However …

Toehold-mediated strand displacement (TMSD) has been used extensively for molecular
sensing and computing in DNA-based molecular circuits. As these circuits grow in …

In designing aerosolized drugs, the challenge lies in achieving optimal penetration and
retention. Existing delivery systems prioritize larger particles for prolonged intrapulmonary …

Toehold-mediated strand displacement (TMSD) is extensively utilized in dynamic DNA
nanotechnology and for a wide range of DNA or RNA-based reaction circuits. Investigation …

Cell-free biosensors are powerful platforms for monitoring human and environmental health.
Here, we expand their capabilities by interfacing them with toehold-mediated strand …

Design strategies for DNA and RNA nanostructures have developed along parallel lines for
the past 30 years, from small structural motifs derived from biology to large …