A growing body of research suggests that short-chain fatty acids (SCFAs), metabolites
produced by intestinal symbiotic bacteria that ferment dietary fibers (DFs), play a crucial role …

The tumour microenvironment is the primary location in which tumour cells and the host
immune system interact. Different immune cell subsets are recruited into the tumour …

In the gastro-intestinal tract, short chain fatty acids (SCFAs) have protective effects on
epithelial cells. However, their effects on inflammatory cytokine production by endothelial …

There is now an abundance of evidence to show that short-chain fatty acids (SCFAs) play an
important role in the maintenance of health and the development of disease. SCFAs are a …

The NF-κB family of inducible transcription factors is activated in response to a variety of
stimuli. Amongst the best-characterized inducers of NF-κB are members of the TNF family of …

Preclinical and clinical studies suggest that inflammation and vascular dysfunction
contribute to the pathogenesis of major depressive disorder (MDD). Chronic social stress …

Innate immune response induces positive inflammatory transducers and regulators in order
to attack pathogens, while simultaneously negative signaling regulators are transcribed to …

Proinflammatory stimuli elicit rapid transcriptional responses via transduced signals to
master regulatory transcription factors. To explore the role of chromatin-dependent signal …

Tumors are cellularly and molecularly heterogeneous, with subsets of undifferentiated
cancer cells exhibiting stem cell-like features (CSCs). Epithelial to mesenchymal transitions …

The chemokine CXCL8 has been found to play an important role in tumor progression in
recent years. CXCL8 activates multiple intracellular signaling pathways by binding to its …