The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …

Background: There is some evidence to suggest that social isolation may be associated with
poor cognitive function in later life. However, findings are inconsistent and there is wide …

Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-
NC) and Alzheimer's disease neuropathologic change (ADNC) are each associated with …

Aluminum (Al) is a ubiquitous substance encountered both naturally (as the third most
abundant element) and intentionally (used in water, foods, pharmaceuticals, and vaccines); …

Astrocytes have essential roles in the central nervous system and are also implicated in the
pathogenesis of neurodegenerative disease. Forming non‐overlapping domains, astrocytes …

Background Population-based autopsy studies provide valuable insights into the causes of
dementia but are limited by sample size and restriction to specific populations …

The spectrum of mixed brain pathologies expands beyond accompanying vascular
pathology in brains with Alzheimer's disease-related pathology. Co-occurrence of …

Political drive to screen for pre-dementia: not evidence based and ignores the harms of
diagnosis Page 1 TOO MUCH MEDICINE Political drive to screen for pre-dementia: not …

The incidence of dementia is expected to double in the next 20 years and will contribute to
heavy social and economic burden. Dementia is caused by neuronal loss that leads to brain …

Alzheimer's disease (AD) and vascular dementia (VaD) are the two most common types of
dementia. Although the combination of these disorders, called 'mixed'dementia, is …