Phosphatidylethanolamine metabolism in health and disease

E Calzada, O Onguka, SM Claypool - … review of cell and molecular biology, 2016 - Elsevier
Phosphatidylethanolamine (PE) is the second most abundant glycerophospholipid in
eukaryotic cells. The existence of four only partially redundant biochemical pathways that …

Extracellular vesicles in the fungi kingdom

M Liebana-Jordan, B Brotons, JM Falcon-Perez… - International Journal of …, 2021 - mdpi.com
Extracellular vesicles (EVs) are membranous, rounded vesicles released by prokaryotic and
eukaryotic cells in their normal and pathophysiological states. These vesicles form a network …

Comparative analysis of Klebsiella pneumoniae genomes identifies a phospholipase D family protein as a novel virulence factor

LMS Lery, L Frangeul, A Tomas, V Passet, AS Almeida… - BMC biology, 2014 - Springer
Background Klebsiella pneumoniae strains are pathogenic to animals and humans, in which
they are both a frequent cause of nosocomial infections and a re-emerging cause of severe …

Mitochondria and fungal pathogenesis: drug tolerance, virulence, and potential for antifungal therapy

M Shingu-Vazquez, A Traven - Eukaryotic cell, 2011 - Am Soc Microbiol
Recently, mitochondria have been identified as important contributors to the virulence and
drug tolerance of human fungal pathogens. In different scenarios, either hypo-or …

Biomembrane lipids: When physics and chemistry join to shape biological activity

F Ramos-Martín, N D'Amelio - Biochimie, 2022 - Elsevier
Biomembranes constitute the first lines of defense of cells. While small molecules can often
permeate cell walls in bacteria and plants, they are generally unable to penetrate the barrier …

Lipid biosynthesis as an antifungal target

J Pan, C Hu, JH Yu - Journal of Fungi, 2018 - mdpi.com
Lipids, commonly including phospholipids, sphingolipids, fatty acids, sterols, and
triacylglycerols (TAGs), are important biomolecules for the viability of all cells …

Lipidomics of Candida albicans biofilms reveals phase-dependent production of phospholipid molecular classes and role for lipid rafts in biofilm formation

AA Lattif, PK Mukherjee, J Chandra… - …, 2011 - microbiologyresearch.org
Candida albicans-associated bloodstream infections are linked to the ability of this yeast to
form biofilms. In this study, we used lipidomics to compare the lipid profiles of C. albicans …

The Significance of Lipids to Biofilm Formation in Candida albicans: An Emerging Perspective

D Alim, S Sircaik, SL Panwar - Journal of Fungi, 2018 - mdpi.com
Candida albicans, the dimorphic opportunistic human fungal pathogen, is capable of
forming highly drug-resistant biofilms in the human host. Formation of biofilm is a multistep …

Cell wall integrity is linked to mitochondria and phospholipid homeostasis in Candida albicans through the activity of the post‐transcriptional regulator Ccr4‐Pop2

MJ Dagley, IE Gentle, TH Beilharz… - Molecular …, 2011 - Wiley Online Library
The cell wall is essential for viability of fungi and is an effective drug target in pathogens
such as Candida albicans. The contribution of post‐transcriptional gene regulators to cell …

Lipid flippase subunit Cdc50 mediates drug resistance and virulence in Cryptococcus neoformans

W Huang, G Liao, GM Baker, Y Wang, R Lau, P Paderu… - MBio, 2016 - Am Soc Microbiol
Cryptococcus neoformans is a human fungal pathogen and a major cause of fungal
meningitis in immunocompromised individuals. Treatment options for cryptococcosis are …