Algorithmic fairness in artificial intelligence for medicine and healthcare

RJ Chen, JJ Wang, DFK Williamson, TY Chen… - Nature biomedical …, 2023 - nature.com
In healthcare, the development and deployment of insufficiently fair systems of artificial
intelligence (AI) can undermine the delivery of equitable care. Assessments of AI models …

Artificial intelligence for digital and computational pathology

AH Song, G Jaume, DFK Williamson, MY Lu… - Nature Reviews …, 2023 - nature.com
Advances in digitizing tissue slides and the fast-paced progress in artificial intelligence,
including deep learning, have boosted the field of computational pathology. This field holds …

A survey on deep learning tools dealing with data scarcity: definitions, challenges, solutions, tips, and applications

L Alzubaidi, J Bai, A Al-Sabaawi, J Santamaría… - Journal of Big Data, 2023 - Springer
Data scarcity is a major challenge when training deep learning (DL) models. DL demands a
large amount of data to achieve exceptional performance. Unfortunately, many applications …

Towards a general-purpose foundation model for computational pathology

RJ Chen, T Ding, MY Lu, DFK Williamson, G Jaume… - Nature Medicine, 2024 - nature.com
Quantitative evaluation of tissue images is crucial for computational pathology (CPath) tasks,
requiring the objective characterization of histopathological entities from whole-slide images …

Fast and scalable search of whole-slide images via self-supervised deep learning

C Chen, MY Lu, DFK Williamson, TY Chen… - Nature Biomedical …, 2022 - nature.com
The adoption of digital pathology has enabled the curation of large repositories of gigapixel
whole-slide images (WSIs). Computationally identifying WSIs with similar morphologic …

[HTML][HTML] A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity

P Meiser, MA Knolle, A Hirschberger, GP de Almeida… - Cancer Cell, 2023 - cell.com
Type 1 conventional dendritic cells (cDC1) can support T cell responses within tumors but
whether this determines protective versus ineffective anti-cancer immunity is poorly …

Generalizable biomarker prediction from cancer pathology slides with self-supervised deep learning: A retrospective multi-centric study

JM Niehues, P Quirke, NP West, HI Grabsch… - Cell reports …, 2023 - cell.com
Deep learning (DL) can predict microsatellite instability (MSI) from routine histopathology
slides of colorectal cancer (CRC). However, it is unclear whether DL can also predict other …

Demographic bias in misdiagnosis by computational pathology models

A Vaidya, RJ Chen, DFK Williamson, AH Song… - Nature Medicine, 2024 - nature.com
Despite increasing numbers of regulatory approvals, deep learning-based computational
pathology systems often overlook the impact of demographic factors on performance …

Neuropathologist-level integrated classification of adult-type diffuse gliomas using deep learning from whole-slide pathological images

W Wang, Y Zhao, L Teng, J Yan, Y Guo, Y Qiu… - Nature …, 2023 - nature.com
Current diagnosis of glioma types requires combining both histological features and
molecular characteristics, which is an expensive and time-consuming procedure …

Overcoming the challenges to implementation of artificial intelligence in pathology

JS Reis-Filho, JN Kather - JNCI: Journal of the National Cancer …, 2023 - academic.oup.com
Pathologists worldwide are facing remarkable challenges with increasing workloads and
lack of time to provide consistently high-quality patient care. The application of artificial …