Translational systems biology of inflammation
Y Vodovotz, M Csete, J Bartels… - PLoS computational …, 2008 - journals.plos.org
Inflammation is a complex, multi-scale biologic response to stress that is also required for
repair and regeneration after injury. Despite the repository of detailed data about the cellular …
repair and regeneration after injury. Despite the repository of detailed data about the cellular …
Sepsis: Something old, something new, and a systems view
Sepsis is a clinical syndrome characterized by a multisystem response to a microbial
pathogenic insult consisting of a mosaic of interconnected biochemical, cellular, and organ …
pathogenic insult consisting of a mosaic of interconnected biochemical, cellular, and organ …
Towards systems immunology of critical illness at scale: from single cell 'omics to digital twins
Y Vodovotz - Trends in immunology, 2023 - cell.com
Single-cell 'omics methodology has yielded unprecedented insights based largely on data-
centric informatics for reducing, and thus interpreting, massive datasets. In parallel …
centric informatics for reducing, and thus interpreting, massive datasets. In parallel …
Mechanistic simulations of inflammation: current state and future prospects
Inflammation is a normal, robust physiological process. It can also be viewed as a complex
system that senses and attempts to resolve homeostatic perturbations initiated from within …
system that senses and attempts to resolve homeostatic perturbations initiated from within …
Modeling the influence of circadian rhythms on the acute inflammatory response
JD Scheff, SE Calvano, SF Lowry… - Journal of theoretical …, 2010 - Elsevier
A wide variety of modeling techniques have been applied towards understanding
inflammation. These models have broad potential applications, from optimizing clinical trials …
inflammation. These models have broad potential applications, from optimizing clinical trials …
The acute inflammatory response in trauma/hemorrhage and traumatic brain injury: current state and emerging prospects
Traumatic injury/hemorrhagic shock (T/HS) elicits an acute inflammatory response that may
result in death. Inflammation describes a coordinated series of molecular, cellular, tissue …
result in death. Inflammation describes a coordinated series of molecular, cellular, tissue …
Insights into the role of chemokines, damage-associated molecular patterns, and lymphocyte-derived mediators from computational models of trauma-induced …
Significance: Traumatic injury elicits a complex, dynamic, multidimensional inflammatory
response that is intertwined with complications such as multiple organ dysfunction and …
response that is intertwined with complications such as multiple organ dysfunction and …
Computational approach to characterize causative factors and molecular indicators of chronic wound inflammation
S Nagaraja, A Wallqvist, J Reifman… - The Journal of …, 2014 - journals.aai.org
Chronic inflammation is rapidly becoming recognized as a key contributor to numerous
pathologies. Despite detailed investigations, understanding of the molecular mechanisms …
pathologies. Despite detailed investigations, understanding of the molecular mechanisms …
A dynamic view of trauma/hemorrhage-induced inflammation in mice: principal drivers and networks
Q Mi, G Constantine, C Ziraldo, A Solovyev, A Torres… - PloS one, 2011 - journals.plos.org
Background Complex biological processes such as acute inflammation induced by
trauma/hemorrhagic shock/(T/HS) are dynamic and multi-dimensional. We utilized …
trauma/hemorrhagic shock/(T/HS) are dynamic and multi-dimensional. We utilized …
Central Role for MCP-1/CCL2 in Injury-Induced Inflammation Revealed by In Vitro, In Silico, and Clinical Studies
The translation of in vitro findings to clinical outcomes is often elusive. Trauma/hemorrhagic
shock (T/HS) results in hepatic hypoxia that drives inflammation. We hypothesize that in …
shock (T/HS) results in hepatic hypoxia that drives inflammation. We hypothesize that in …