α-Synuclein is a presynaptic neuronal protein that is linked genetically and
neuropathologically to Parkinson's disease (PD). α-Synuclein may contribute to PD …

The aggregation of alpha synuclein (α‐syn) is a neuropathological feature that defines a
spectrum of disorders collectively termed synucleinopathies, and of these, Parkinson's …

We used a collection of 708 prospectively collected autopsied brains to assess the
methylation state of the brain's DNA in relation to Alzheimer's disease (AD). We found that …

GLT-1 (EAAT2; slc1a2) is the major glutamate transporter in the brain, and is predominantly
expressed in astrocytes, but at lower levels also in excitatory terminals. We generated a …

Substantial genetic, neuropathological, and biochemical evidence implicates the
presynaptic neuronal protein α-synuclein in Parkinson's disease and related Lewy body …

Mitochondrial impairment is a well-established pathological pathway implicated in
Parkinson's disease (PD). Defects of the complex I of the mitochondrial respiratory chain …

α-Synuclein physiologically chaperones SNARE-complex assembly at the synapse but
pathologically misfolds into neurotoxic aggregates that are characteristic for …

Summary α-synuclein, β-synuclein, and γ-synuclein are abundantly expressed proteins in
the vertebrate nervous system. α-synuclein functions in neurotransmitter release by binding …

Genetic studies of Parkinson's disease over the last decade or more have revolutionized our
understanding of this condition. α‐Synuclein was the first gene to be linked to Parkinson's …

In view of the population-specific heterogeneity in reported genetic risk factors for
Parkinson's disease (PD), we conducted a genome-wide association study (GWAS) in a …