Octanol-water partition ratio is the most common way of expressing the lipophilicity of a
compound, and it is defined as the ratio of the concentration of a solute in a water-saturated …

Malaria is one of the most prevalent and devastating infectious diseases of our time. Yet,
unfortunately, apart from artemisinin combination therapies there are relatively few effective …

Synthesis and antifungal activity of hybrids of thiazolo [4, 5-d] pyrimidines with (1H-1, 2, 4)
triazoles are presented. The solubility and lipophilicity of compounds was assessed and it …

Lipophilicity, quantified by the logarithm of the n-octanol/water partition coefficient (logP) or
the distribution coefficient (logD), is a crucial parameter for modelling biological partition or …

Lipophilicity is an important parameter for any potential drug candidate. Accurate and
efficient lipophilicity measurements facilitate the development of high-quality predictive in …

Microfluidic platforms provide several advantages for liquid–liquid extraction (LLE)
processes over conventional methods, for example with respect to lower consumption of …

Modern small molecule drug design requires the optimization of not only the binding
characteristics of the molecule but also its physicochemical properties for ADMET …

Cyclodextrins are very important excipients in the pharmaceutical industry. Given the
multitude of native and semisynthetic cyclodextrin derivatives, there is a need for a rapid and …

Raman spectroscopy has proven to be a powerful tool for the highly efficient and automated
determination of liquid-liquid equilibria (LLE) in parallel microfluidic flows. However, a stable …

The membrane microseparator is a milliliter-scale flow chemistry module that continuously
separates a biphasic flow through a PTFE microporous membrane. It has found a wide …