Essential tremor (ET) is a centrally driven tremor. It is meanwhile well established that it does
not emerge from one single oscillator but an oscillatory network comprising most parts of the …

Background: The pathophysiology underlying essential tremor (ET) still is poorly
understood. Recent research suggests a pivotal role of the cerebellum in tremor genesis …

BACKGROUND: Cumulative adversity and stress are associated with risk of psychiatric
disorders. While basic science studies show repeated and chronic stress effects on …

Objective: Alcoholism is associated with gray matter volume deficits in frontal and other brain
regions. Whether persistent brain volume deficits in abstinence are predictive of subsequent …

Background Essential tremor is regarded to be a disease of the central nervous system.
Neuroimaging is a rapidly growing field with potential benefits to both diagnostics and …

Background The degenerative cerebellar ataxias comprise a large and heterogeneous
group of neurological diseases whose hallmark clinical feature is ataxia, and which are …

Importance Substance use disorders (SUDs) are among the most common sequelae of
childhood maltreatment, yet the independent contributions of SUDs and childhood …

Structural changes in Purkinje cells have been identified in the essential tremor cerebellum,
although the mechanisms that underlie these changes remain poorly understood. Climbing …

Essential tremor (ET) is one of the most common neurologic diseases. Increased numbers of
torpedoes and Purkinje cell (PC) loss have been documented in the brains of patients with …

Objective There is growing evidence that cerebellum plays a crucial role in cognition and
emotional regulation. Cerebellum is likely to be involved in the physiopathology of both …