Many different strategies can be found in the literature to model organ physiology, tissue
functionality, and disease in vitro; however, most of these models lack the physiological fluid …

Radiation therapy is one of the most commonly used treatments for head and neck cancers,
but it often leads to radiation-induced brain injury. Patients with radiation-induced brain …

The blood-brain barrier (BBB) is a highly selective barrier that ensures a homeostatic
environment for the central nervous system (CNS). BBB dysfunction, inflammation, and …

Cosmic radiation is the most serious risk that will be encountered during the planned
missions to the Moon and Mars. There is a compelling need to understand the effects, safety …

Impairment of the central nervous system (CNS) poses a significant health risk for astronauts
during long-duration space missions. In this study, we employed an innovative approach by …

The number of long duration human spaceflights has increased substantially over the past
15 years, leading to the discovery of numerous effects on the CNS. Microgravity results in …

Introduction Exposure to space conditions during crewed long-term exploration missions
can cause several health risks for astronauts. Space radiation, isolation and microgravity are …

Galactic cosmic radiation (GCR) is one of the most serious risks posed to astronauts during
missions to the Moon and Mars. Experimental models capable of recapitulating human …

Impairment of the central nervous system (CNS) functions in astronauts is a major health risk
for long-duration space missions. Here, for the first time, we combine single-cell multiomics …

Background Early brain injury (EBI) caused by inflammatory responses in acute phase of
Intracerebral hemorrhage (ICH) plays a vital role in the pathological progression of ICH …