Chromosomal instability in cancer consists of dynamic changes to the number and structure
of chromosomes,. The resulting diversity in somatic copy number alterations (SCNAs) may …

Aneuploidy, chromosomal instability, somatic copy-number alterations, and whole-genome
doubling (WGD) play key roles in cancer evolution and provide information for the complex …

Cancer is a disease of cellular evolution. For this cellular evolution to take place, a
population of cells must contain functional heterogeneity and an assessment of this …

Chromosomal instability (CIN)—persistent chromosome gain or loss through abnormal
mitotic segregation—is a hallmark of cancer that drives aneuploidy. Intrinsic chromosome …

Quantitative measures of CIN are crucial to our understanding of its role in cancer.
Technological advances have changed the way CIN is quantified, offering increased …

Chromosomal instability (CIN) drives the formation of karyotype aberrations in cancer cells
and is a major contributor to intra-tumour heterogeneity, metastasis, and therapy resistance …

Phylogenetic trees based on copy number profiles from multiple samples of a patient are
helpful to understand cancer evolution. Here, we develop a new maximum likelihood …

Spindle assembly checkpoint (SAC) is a crucial safeguard mechanism of mitosis fidelity that
ensures equal division of duplicated chromosomes to the two progeny cells. Impaired SAC …

Most tumors have abnormal karyotypes, which arise from mistakes during mitotic division of
healthy euploid cells and evolve through numerous complex mechanisms. In a recent …

The phenotypic efficacy of somatic copy number alterations (SCNAs) stems from their
incidence per base pair of the genome, which is orders of magnitudes greater than that of …