Alzheimer's disease, the leading cause of dementia in the elderly, is a neurodegenerative
condition characterized by accumulation of amyloid plaques and neurofibrillary tangles in …

Lung endothelia in the arteries, capillaries, and veins are heterogeneous in structure and
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …

The activated form of coagulation factor XIII (FXIII-A2B2), FXIII-A*, is a hemostatic enzyme
essential for inhibiting fibrinolysis by irreversibly crosslinking fibrin and antifibrinolytic …

The recent recognition that Alzheimer disease-like pathology may be found in chronic
traumatic encephalopathy (CTE) even after acute mild traumatic brain injury (mTBI) has …

Increased cerebrovascular amyloid-β (Aβ) deposition represents the main pathogenic
mechanisms characterizing Alzheimer's disease (AD) and cerebral amyloid angiopathy …

Alzheimer's disease (AD) is one of the most prevalent forms of neurodegenerative disorders.
Previously, we have shown that in vivo administration of an IL-17 neutralizing antibody (IL …

Calcific aortic valve disease (CAVD) is the most prevalent valvular heart disease in the
developed world, yet no pharmacological therapy exists. Here, we hypothesize that the …

Abstract Human factor XIIIa (FXIIIa) is a multifunctional transglutaminase with a significant
role in hemostasis. FXIIIa catalyzes the last step in the coagulation process. It stabilizes the …

Transglutaminase factor XIII (FXIII) is essential for hemostasis, wound healing, and
pregnancy maintenance. Plasma FXIII is composed of A and B subunit dimers synthesized …

Alzheimer's disease (AD) is the most common form of dementia and without readily
available clinical biomarkers. Blood-derived proteins are routinely used for diagnostics; …