Painful diabetic peripheral neuropathy: Role of oxidative stress and central sensitisation

D Ye, TJ Fairchild, L Vo, PD Drummond - Diabetic Medicine, 2022 - Wiley Online Library
Aims Diabetic peripheral neuropathy (DPN) occurs in about half of people with diabetes, of
whom a quarter may develop chronic pain. Pain may remain for years yet be difficult to treat …

VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody

L Micheli, C Parisio, E Lucarini, A Vona, A Toti… - Journal of Experimental …, 2021 - Springer
Background Neuropathic pain is a clinically relevant adverse effect of several anticancer
drugs that markedly impairs patients' quality of life and frequently leads to dose reduction or …

Redefining distal symmetrical polyneuropathy features in type 1 diabetes: a systematic review

E Galosi, X Hu, N Michael, JR Nyengaard, A Truini… - Acta Diabetologica, 2022 - Springer
Diabetic neuropathy is among the most frequent complications of both type 1 (T1DM) and
type 2 diabetes (T2DM) and commonly manifests as a distal symmetrical polyneuropathy …

Early life cisplatin exposure induces nerve growth factor mediated neuroinflammation and chemotherapy induced neuropathic pain

MDV Lobo, L Hardowar, T Valentine… - Disease Models & …, 2024 - journals.biologists.com
Chemotherapy-induced neuropathic pain (CINP) is a common adverse health related
comorbidity that manifests later in life in paediatric cancer patients. Current analgesia is …

[HTML][HTML] Cisplatin induced alterations in nociceptor developmental trajectory elicits a TrkA dependent platinum-based chemotherapy induced neuropathic pain

L Hardowar, T Valentine, MDV Lobo, J Corbett, B Owen… - Neuroscience, 2024 - Elsevier
Cisplatin-based chemotherapy is a common treatment for paediatric cancer. Unfortunately,
cisplatin treatment causes neuropathic pain, a highly prevalent adverse health related …

Neuroprotective Effects of a Hydrogen Sulfide Donor in Streptozotocin-Induced Diabetic Rats

AMF Shayea, WM Renno, B Qabazard… - International Journal of …, 2023 - mdpi.com
Diabetic neuropathy is an important long-term complication of diabetes. This study explored
the hypothesis that hydrogen sulfide (H2S) ameliorates neuropathic pain by controlling …

Hypoxia-induced carbonic anhydrase mediated dorsal horn neuron activation and induction of neuropathic pain

MEDV Lobo, N Weir, L Hardowar, Y Al Ojaimi… - Pain, 2022 - journals.lww.com
Neuropathic pain, such as that seen in diabetes mellitus, results in part from central
sensitisation in the dorsal horn. However, the mechanisms responsible for such sensitisation …

Blocking endothelial apoptosis revascularizes the retina in a model of ischemic retinopathy

ZL Grant, L Whitehead, VHY Wong… - The Journal of …, 2020 - Am Soc Clin Investig
Aberrant, neovascular retinal blood vessel growth is a vision-threatening complication in
ischemic retinal diseases. It is driven by retinal hypoxia frequently caused by capillary …

Non‐invasive measurement of retinal permeability in a diabetic rat model

CL Allen, NK Malhi, JL Whatmore, DO Bates… - …, 2020 - Wiley Online Library
Objective The gold standard for measuring blood‐retinal barrier permeability is the Evans
blue assay. However, this technique has limitations in vivo, including non‐specific tissue …

Does diabetes affect the surgical outcomes in cases with cervical ossification of the posterior longitudinal ligament? A multicenter study from Asia Pacific Spine Study …

N Nagoshi, K Watanabe, M Nakamura… - Global Spine …, 2023 - journals.sagepub.com
Study Design: Retrospective multicenter study. Objectives: To evaluate the surgical
outcomes of cervical ossification of the posterior longitudinal ligament (OPLL) in diabetes …