Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies

NC Noronha, A Mizukami, C Caliári-Oliveira… - Stem cell research & …, 2019 - Springer
Multipotent mesenchymal stromal cells (MSC) have been widely explored for cell-based
therapy of immune-mediated, inflammatory, and degenerative diseases, due to their …

Biomaterials functionalized with MSC secreted extracellular vesicles and soluble factors for tissue regeneration

MÁ Brennan, P Layrolle… - Advanced functional …, 2020 - Wiley Online Library
The therapeutic benefits of mesenchymal stromal cell (MSC) transplantation are attributed to
their secreted factors, including extracellular vesicles (EVs) and soluble factors. The …

Potential pre-activation strategies for improving therapeutic efficacy of mesenchymal stem cells: current status and future prospects

M Li, Y Jiang, Q Hou, Y Zhao, L Zhong, X Fu - Stem cell research & …, 2022 - Springer
Mesenchymal stem cell (MSC)-based therapy has been considered as a promising
approach targeting a variety of intractable diseases due to remarkable multiple effect of …

Therapeutic properties of mesenchymal stromal/stem cells: the need of cell priming for cell-free therapies in regenerative medicine

V Miceli, M Bulati, G Iannolo, G Zito, A Gallo… - International Journal of …, 2021 - mdpi.com
Mesenchymal stromal/stem cells (MSCs) are multipotent adult stem cells that support
homeostasis during tissue regeneration. In the last decade, cell therapies based on the use …

The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke

CJ Cunningham, E Redondo-Castro… - Journal of Cerebral …, 2018 - journals.sagepub.com
Mesenchymal stem cells (MSCs) hold great potential as a regenerative therapy for stroke,
leading to increased repair and functional recovery in animal models of cerebral ischaemia …

Cerium Oxide Nanoparticle Incorporated Electrospun Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Membranes for Diabetic Wound Healing Applications

R Augustine, A Hasan, NK Patan, YB Dalvi… - ACS Biomaterials …, 2019 - ACS Publications
Insufficient cell proliferation, cell migration, and angiogenesis are among the major causes
for nonhealing of chronic diabetic wounds. Incorporation of cerium oxide nanoparticles …

Injectable and tunable hyaluronic acid hydrogels releasing chemotactic and angiogenic growth factors for endodontic regeneration

CR Silva, PS Babo, M Gulino, L Costa, JM Oliveira… - Acta biomaterialia, 2018 - Elsevier
Bioengineered soft tissues on any meaningful scale or complexity must incorporate aspects
of the functional tissue, namely a vasculature, providing cells oxygen and nutrients critical for …

Functional enhancement strategies for immunomodulation of mesenchymal stem cells and their therapeutic application

BC Lee, KS Kang - Stem cell research & therapy, 2020 - Springer
Mesenchymal stem cells (MSCs) have recently been considered a promising alternative
treatment for diverse immune disorders due to their unique biomedical potentials including …

Pathophysiology of preeclampsia: the role of exosomes

K Matsubara, Y Matsubara, Y Uchikura… - International journal of …, 2021 - mdpi.com
The pathogenesis of preeclampsia begins when a fertilized egg infiltrates the decidua,
resulting in implantation failure (eg, due to extravillous trophoblast infiltration disturbance …

In-vitro models of biocompatibility testing for restorative dental materials: From 2D cultures to organs on-a-chip

CM Franca, G de Souza Balbinot, D Cunha… - Acta biomaterialia, 2022 - Elsevier
Dental caries is a biofilm-mediated, diet-modulated, multifactorial and dynamic disease that
affects more than 90% of adults in Western countries. The current treatment for decayed …