Cardiovascular disease is the leading global health concern and responsible for more
deaths worldwide than any other type of disorder. Atherosclerosis is a chronic inflammatory …

Background: Circulating branched-chain amino acids (BCAAs; isoleucine, leucine, and
valine) are strong predictors of type 2 diabetes mellitus (T2D), but their association with …

Vascular disease is one of the top five causes of death and affects a variety of other
diseases, such as heart, nervous system, and metabolic disorders. Vascular dysfunction is a …

Background It has been suggested that serum branched-chain amino acids (BCAAs) are
associated with the incident, progression and prognostic of type 2 diabetes. However, the …

This study tested the hypothesis that elevated L-leucine concentrations in plasma reduce
nitric oxide (NO) synthesis by endothelial cells (ECs) and affect adiposity in obese rats …

In this article, we review the biochemistry of BCAAs, their potential contribution to
cardiometabolic risk, the available evidence from molecular epidemiologic studies to date …

Background and aim Several recent studies have found an independent relationship
between levels of plasma branched-chain amino acids (BCAAs) and risk factors for coronary …

Despite significant advances in medical treatments and drug development, atherosclerotic
cardiovascular disease (ASCVD) remains a leading cause of death worldwide …

Aims: Nonalcoholic fatty liver disease (NAFLD) is known to be associated with
atherosclerosis. This study focused on upstream changes in the process by which NAFLD …

Reduced availability of nitric oxide (NO) in the vasculature is a major factor contributing to
the impaired action of insulin on blood flow and, therefore, insulin resistance in obese and …