Babies who are small at birth or during infancy have increased rates of cardiovascular
disease and non-insulin-dependent diabetes as adults. Some of these babies have low …

The thrifty phenotype hypothesis proposes that the epidemiological associations between
poor fetal and infant growth and the subsequent development of type 2 diabetes and the …

1. Many human fetuses have to adapt to a limited supply of nutrients. In doing so they
permanently change their structure and metabolism. 2. These'programmed'changes may be …

The “fetal” or “early” origins of adult disease hypothesis was originally put forward by David
Barker and colleagues and stated that environmental factors, particularly nutrition, act in …

Numerous clinical studies associate an adverse prenatal environment with the development
of cardio-metabolic disorders and neuroendocrine dysfunction, as well as an increased risk …

Much telomere loss takes place during the period of most rapid growth when cell
proliferation and potentially energy expenditure are high. Fast growth is linked to reduced …

Objective: To examine whether catch-up growth during childhood modifies the increased
risk of death from coronary heart disease that is associated with reduced intrauterine growth …

OBJECTIVE To assess the effect of prenatal exposure to maternal malnutrition on coronary
heart disease in people born around the time of the Dutch famine, 1944–45. DESIGN …

That events during critical or sensitive periods of development may “program” long-term or
life-time structure or function of the organism is well recognized. Evidence for programming …

Many human fetuses have to adapt to a limited supply of nutrients. In doing so they
permanently change their structure and metabolism. These programmed changes may be …