Abstract Purpose of Review Quantification of the morphology of osteocyte lacunae has
become a powerful tool to investigate bone metabolism, pathologies and aging. This review …

Prostate cancer (PCa) is an increasingly prevalent health problem in the developed world.
Effective treatment options exist for localized PCa, but metastatic PCa has fewer treatment …

Bone is one of the most common sites of tumor metastases. During the last step of bone
metastasis, cancer cells colonize and disrupt the bone matrix, which is maintained mainly by …

Breast cancer bone metastases increase fracture risk and are a major cause of morbidity
and mortality among women. Upon colonization by tumor cells, the bone microenvironment …

Abstract Purpose of Review The goal of this review is to summarize recent findings related to
modifications in osteocyte lacunar and canalicular morphology due to physiological and …

Abstract Purpose of Review The purpose of this review is to discuss the molecular
mechanisms involved in osteocyte dendrite formation, summarize the similarities between …

Metastatic bone disease is a complex condition resulting from the migration and colonization
of cancer cells from their primary site to the bone microenvironment, where they typically …

In multiple myeloma (MM), communication via Notch signaling in the tumor niche stimulates
tumor progression and bone destruction. We previously showed that osteocytes activate …

Abstract Purpose of Review While the function of osteocytes under physiologic conditions is
well defined, their role and involvement in cancer disease remains relatively unexplored …

Simple Summary This review describes how osteocytes, the most abundant cells in bone,
act in cancers that grow in bone. It summarizes how cancer cells reprogram osteocytes to …