TCR recognition of peptide–MHC-I: Rule makers and breakers
T cells are a critical part of the adaptive immune system that are able to distinguish between
healthy and unhealthy cells. Upon recognition of protein fragments (peptides), activated T …
healthy and unhealthy cells. Upon recognition of protein fragments (peptides), activated T …
Using T cell receptor repertoires to understand the principles of adaptive immune recognition
Adaptive immune recognition is mediated by antigen receptors on B and T cells generated
by somatic recombination during lineage development. The high level of diversity resulting …
by somatic recombination during lineage development. The high level of diversity resulting …
CD8+ T cells specific for conserved coronavirus epitopes correlate with milder disease in patients with COVID-19
V Mallajosyula, C Ganjavi, S Chakraborty… - Science …, 2021 - science.org
A central feature of the SARS-CoV-2 pandemic is that some individuals become severely ill
or die, whereas others have only a mild disease course or are asymptomatic. Here, we …
or die, whereas others have only a mild disease course or are asymptomatic. Here, we …
Antigen identification and high-throughput interaction mapping by reprogramming viral entry
CS Dobson, AN Reich, S Gaglione, BE Smith, EJ Kim… - Nature …, 2022 - nature.com
Deciphering immune recognition is critical for understanding a broad range of diseases and
for the development of effective vaccines and immunotherapies. Efforts to do so are limited …
for the development of effective vaccines and immunotherapies. Efforts to do so are limited …
Sequence and structural analyses reveal distinct and highly diverse human CD8+ TCR repertoires to immunodominant viral antigens
A diverse T cell receptor (TCR) repertoire is essential for controlling viral infections.
However, information about TCR repertoires to defined viral antigens is limited. We …
However, information about TCR repertoires to defined viral antigens is limited. We …
Emerging concepts in TCR specificity: rationalizing and (maybe) predicting outcomes
T cell specificity emerges from a myriad of processes, ranging from the biological pathways
that control T cell signaling to the structural and physical mechanisms that influence how …
that control T cell signaling to the structural and physical mechanisms that influence how …
Massively parallel interrogation and mining of natively paired human TCRαβ repertoires
MJ Spindler, AL Nelson, EK Wagner… - Nature …, 2020 - nature.com
T cells engineered to express antigen-specific T cell receptors (TCRs) are potent therapies
for viral infections and cancer. However, efficient identification of clinical candidate TCRs is …
for viral infections and cancer. However, efficient identification of clinical candidate TCRs is …
Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+ T cell epitope
A keystone of antiviral immunity is CD8+ T cell recognition of viral peptides bound to MHC-I
proteins. The recognition modes of individual T cell receptors (TCRs) have been studied in …
proteins. The recognition modes of individual T cell receptors (TCRs) have been studied in …
Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen
Adoptive cell therapy (ACT) with tumor-specific T cells can mediate cancer regression. The
main target of tumor-specific T cells are neoantigens arising from mutations in self-proteins …
main target of tumor-specific T cells are neoantigens arising from mutations in self-proteins …
Antigen identification for HLA class I–and HLA class II–restricted T cell receptors using cytokine-capturing antigen-presenting cells
MN Lee, M Meyerson - Science immunology, 2021 - science.org
A major limitation to understanding the associations of human leukocyte antigen (HLA) and
CD8+ and CD4+ T cell receptor (TCR) genes with disease pathophysiology is the …
CD8+ and CD4+ T cell receptor (TCR) genes with disease pathophysiology is the …