Recent developments in microbiome research suggest that the gut microbiome may
remotely modulate central and peripheral neuronal processes, ranging from early brain …

Vitamin K (VK) is a ligand of the pregnane X receptor (PXR), which plays a critical role in the
detoxification of xenobiotics and metabolism of bile acids. VK1 may reduce the risk of death …

The microbiome-gut-brain-axis is a complex phenomenon spanning several dynamic
systems in the body which can be parsed at a molecular, cellular, physiological and …

Background Cerebral ischemia-reperfusion injury (CIRI), a subsequent injury caused by
thrombolytic reperfusion post ischemic stroke (IS). Naotaifang (NTF) formula, a novel …

Abstract Background: Menaquinone-4 (MK-4), the isoform of vitamin K2 in the brain, exerts
neuroprotective effects against a variety of central nervous system disorders. This study …

Renal ischemia-reperfusion injury (IRI) is considered as a major cause of acute kidney
injury. In this study, we investigated the role of the NF-κB signaling pathway and …

Background and purpose Acute ischaemic stroke (AIS) is a vital cause of mortality and
morbidity in China. Many AIS patients develop early neurological deterioration (END). This …

Stroke is the leading cause of global mortality and disability. Cerebral edema and
intracranial hypertension are common complications of cerebral infarction and the major …

Parkinson's disease (PD) is a degenerative disease that affects approximately 6.1 million
people and is primarily caused by the loss of dopaminergic neurons. Naphthoquinones …

Diabetes, a chronic metabolic disease, affects approximately 422 million people and leads
to 1.5 million deaths every year, It is found that 45% of individuals with diabetes eventually …