The accumulation of unfolded proteins in the endoplasmic reticulum (ER) represents a
cellular stress induced by multiple stimuli and pathological conditions. These include …

Disturbances in the normal functions of the ER lead to an evolutionarily conserved cell
stress response, the unfolded protein response, which is aimed initially at compensating for …

BCL-2 was the first anti-death gene discovered, a milestone with far reaching implications
for tumor biology. Multiple members of the human Bcl-2 family of apoptosis-regulating …

We investigated the role of glycogen synthase kinase-3 (GSK-3), which is inactivated by
AKT, for its role in the regulation of apoptosis. Upon IL-3 withdrawal, protein levels of MCL-1 …

The members of the Bcl-2 family are the central regulators of various cell death modalities.
Some of these proteins contribute to apoptosis, while others counteract this type of …

Cellular growth and proliferation are coordinated during organogenesis. Misregulation of
these processes leads to pathological conditions such as cancer. Tuberous sclerosis (TSC) …

Screening for genes that reprogram cancer cells for the tumor reversion switch identified
TCTP (encoding translationally controlled tumor protein) as a crucial regulator of apoptosis …

Translationally controlled tumor protein (TCTP) is a potential target for cancer therapy. It
functions as a growth regulating protein implicated in the TSC1–TSC2–mTOR pathway or a …

Translationally controlled Tumor Protein (TCTP) is an evolutionally highly conserved protein
which has been implicated in many cellular functions that are related to cell growth, death …

How cells become malignant has preoccupied scientists for over a century. However, the
converse question is also valid: are tumour cells capable of reverting from their malignant …