Organs-on-chips: into the next decade

LA Low, C Mummery, BR Berridge, CP Austin… - Nature Reviews Drug …, 2021 - nature.com
Abstract Organs-on-chips (OoCs), also known as microphysiological systems or 'tissue
chips'(the terms are synonymous), have attracted substantial interest in recent years owing …

IL-4 and IL-13 signaling in allergic airway disease

N Gour, M Wills-Karp - Cytokine, 2015 - Elsevier
Aberrant production of the prototypical type 2 cytokines, interleukin (IL)-4 and IL-13 has long
been associated with the pathogenesis of allergic disorders. Despite tremendous scientific …

Lung-on-a-chip: the future of respiratory disease models and pharmacological studies

J Shrestha, S Razavi Bazaz… - Critical reviews in …, 2020 - Taylor & Francis
Abstract Recently, organ-on-a-chip models, which are microfluidic devices that mimic the
cellular architecture and physiological environment of an organ, have been developed and …

Recent advances in lung-on-a-chip models

I Francis, J Shrestha, KR Paudel, PM Hansbro… - Drug Discovery …, 2022 - Elsevier
Highlights•Transition from conventional 2D models to 3D and advanced lung-on-a-chip
models.•Recent advances in lung-on-a-chip platforms and their implementation.•Numerous …

Microfluidic tissue engineering and bio‐actuation

M Filippi, T Buchner, O Yasa, S Weirich… - Advanced …, 2022 - Wiley Online Library
Bio‐hybrid technologies aim to replicate the unique capabilities of biological systems that
could surpass advanced artificial technologies. Soft bio‐hybrid robots consist of synthetic …

A 3D human lung-on-a-chip model for nanotoxicity testing

M Zhang, C Xu, L Jiang, J Qin - Toxicology research, 2018 - academic.oup.com
The prevalent application of nanoparticles (NPs) has drawn intense concerns about their
impact on the environment and human health. Inhalation of NPs is the major route of NP …

Microfluidics: a new tool for modeling cancer–immune interactions

A Boussommier-Calleja, R Li, MB Chen, SC Wong… - Trends in cancer, 2016 - cell.com
In recognition of the enormous potential of immunotherapies against cancer, research into
the interactions between tumor and immune cells has accelerated, leading to the recent FDA …

Skeletal muscle-on-a-chip: an in vitro model to evaluate tissue formation and injury

G Agrawal, A Aung, S Varghese - Lab on a Chip, 2017 - pubs.rsc.org
Engineered skeletal muscle tissues can be used for in vitro studies that require
physiologically relevant models of native tissues. Herein, we describe the development of a …

Microfluidic lumen-based systems for advancing tubular organ modeling

M Virumbrales-Muñoz, JM Ayuso, MM Gong… - Chemical Society …, 2020 - pubs.rsc.org
Microfluidic lumen-based systems are microscale models that recapitulate the anatomy and
physiology of tubular organs. These technologies can mimic human pathophysiology and …

[HTML][HTML] Three-dimensional cell cultures: the bridge between in vitro and in vivo models

O Urzì, R Gasparro, E Costanzo, A De Luca… - International Journal of …, 2023 - mdpi.com
Although historically, the traditional bidimensional in vitro cell system has been widely used
in research, providing much fundamental information regarding cellular functions and …