Recent successes illustrate the role of mass spectrometry-based proteomics as an
indispensable tool for molecular and cellular biology and for the emerging field of systems …

Post-translational modifications modulate the activity of most eukaryote proteins. Analysis of
these modifications presents formidable challenges but their determination generates …

Cells from all kingdoms of life produce extracellular vesicles (EVs). Their cargo is protected
from the environment by the surrounding lipid bilayer. EVs from many organisms have been …

Peptide sequence analysis using a combination of gas-phase ion/ion chemistry and tandem
mass spectrometry (MS/MS) is demonstrated. Singly charged anthracene anions transfer an …

The fungal pathogen Candida albicans can form biofilms that protect it from drugs and the
immune system. The biofilm cells release extracellular vesicles (EVs) that promote …

▪ Abstract A decade after the discovery of electrospray and matrix-assisted laser desorption
ionization (MALDI), methods that finally allowed gentle ionization of large biomolecules …

Protein kinases are coded by more than 2,000 genes and thus constitute the largest single
enzyme family in the human genome. Most cellular processes are in fact regulated by the …

Virulence of Candida is linked with its ability to form biofilms. Once established, biofilm
infections are nearly impossible to eradicate. Biofilm cells live immersed in a self-produced …

Extracellular vesicles mediate community interactions among cells ranging from unicellular
microbes to complex vertebrates. Extracellular vesicles of the fungal pathogen Candida …

This review provides a broad overview of recent Fourier transform ion cyclotron resonance
(FTICR) applications and technological developments relevant to the field of proteomics …