The Natural Biotic Environment of Caenorhabditis elegans

H Schulenburg, MA Félix - Genetics, 2017 - academic.oup.com
Organisms evolve in response to their natural environment. Consideration of natural
ecological parameters are thus of key importance for our understanding of an organism's …

C. elegans outside the Petri dish

L Frézal, MA Félix - elife, 2015 - elifesciences.org
The roundworm Caenorhabditis elegans has risen to the status of a top model organism for
biological research in the last fifty years. Among laboratory animals, this tiny nematode is …

Improved Mos1-mediated transgenesis in C. elegans

C Frøkjær-Jensen, MW Davis, M Ailion… - Nature methods, 2012 - nature.com
To the Editor: The ability to add or delete genes to the genome of genetic model organisms
is essential. Previously, we had developed methods based on the Mos1 transposon1 to …

Random and targeted transgene insertion in Caenorhabditis elegans using a modified Mos1 transposon

C Frøkjær-Jensen, MW Davis, M Sarov, J Taylor… - Nature …, 2014 - nature.com
We have generated a recombinant Mos1 transposon that can insert up to 45-kb transgenes
into the Caenorhabditis elegans genome. The minimal Mos1 transposon (miniMos) is 550 …

Cleave and Rescue, a novel selfish genetic element and general strategy for gene drive

G Oberhofer, T Ivy, BA Hay - Proceedings of the National …, 2019 - National Acad Sciences
There is great interest in being able to spread beneficial traits throughout wild populations in
ways that are self-sustaining. Here, we describe a chromosomal selfish genetic element …

[HTML][HTML] History of research on C. elegans and other free-living nematodes as model organisms

VM Nigon, MA Félix - WormBook: The Online Review of C. elegans …, 2018 - ncbi.nlm.nih.gov
The nematode Caenorhabditis elegans is now a major model organism in biology. The
choice of Sydney Brenner to adopt this species in the mid-1960s and the success of his …

Genetic conflicts: the usual suspects and beyond

RN McLaughlin Jr, HS Malik - Journal of Experimental …, 2017 - journals.biologists.com
Selfishness is pervasive and manifests at all scales of biology, from societies, to individuals,
to genetic elements within a genome. The relentless struggle to seek evolutionary …

Manipulating the destiny of wild populations using CRISPR

R Raban, JM Marshall, BA Hay… - Annual review of …, 2023 - annualreviews.org
Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …

Two-By-One model of cytoplasmic incompatibility: Synthetic recapitulation by transgenic expression of cifA and cifB in Drosophila

JD Shropshire, SR Bordenstein - PLoS genetics, 2019 - journals.plos.org
Wolbachia are maternally inherited bacteria that infect arthropod species worldwide and are
deployed in vector control to curb arboviral spread using cytoplasmic incompatibility (CI). CI …

From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation

KS Evans, MH van Wijk, PT McGrath, EC Andersen… - Trends in Genetics, 2021 - cell.com
Although many studies have examined quantitative trait variation across many species, only
a small number of genes and thereby molecular mechanisms have been discovered …