Abstract Glycoside hydrolase family 18 (GH18) chitinases, which catalyze the
biodegradation of β-1, 4 glycosidic bond in amino polysaccharides via a substrate-assisted …

Fragment-based drug discovery is a strategy widely used in both academia and
pharmaceutical companies to generate small-molecule protein inhibitors and drug …

Click chemistry has emerged as a valuable tool for rapid compound synthesis, presenting
notable advantages and convenience in the exploration of potential drug candidates. In …

Herein, we demonstrate for the first time that noncanonical DNA can direct macrocyclization‐
like challenging reactions to synthesize gene modulators. The planar G‐quartets present in …

Protein‐templated fragment ligation is a novel concept to support drug discovery and can
help to improve the efficacy of protein ligands. Protein‐templated fragment ligations are …

Chitinases not only play vital roles in the human innate immune system but are also
essential for the development of pathogenic fungi and pests. Chitinase inhibitors are efficient …

The structures and biological activities of natural products have often provided inspiration in
drug discovery. The functional benefits of natural products to the host organism steers the …

For the last 15 years, kinetic target-guided syntheses, including in situ click chemistry, have
been used as alternative methods to find ligands to therapeutically relevant proteins. In this …

Chitinases are important glycoside hydrolases that are closely related to bacterial
pathogenesis, fungal cell wall remodelling, and insect moulting. Consequently, chitinases …

Artificial multivalent recognition systems offer promising perspectives for developing
synthetic compounds capable of interacting effectively and selectively with biomolecules in …