Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

Hypoxia is an integral component of the tumor microenvironment. Either as chronic or
cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible …

Abstract Treatment of primary intraocular uveal melanoma has developed considerably, its
driver genes are largely unraveled, and the ways to assess its risk for metastases are very …

Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. UMs
are usually initiated by a mutation in GNAQ or GNA11, unlike cutaneous melanomas, which …

Adaptation to the loss of O2 is regulated via the activity of hypoxia-inducible factors such as
Hypoxia-Inducible Factor-1 (HIF-1). HIF-1 acts as a main transcriptional mediator in the …

Hypoxia, a condition of low oxygen availability, is a hallmark of tumour microenvironment
and promotes cancer progression and resistance to therapy. Many studies reported the …

Uveal melanoma is the most common type of intraocular cancer with a low mean annual
incidence of 5-10 cases per million. Tumours are located in the choroid (90%), ciliary body …

Among Uveal Melanoma (UM) driver mutations, those involving GNAQ or GNA11 genes are
the most frequent, while a minor fraction of tumors bears mutations in the PLCB4 or …

Hypoxia and elevated extracellular acidification are prevalent features of solid tumors and
they are often shown to facilitate cancer progression and drug resistance. In this review, we …

Here, we critically evaluated the knowledge on cutaneous melanoma (CM) and uveal
melanoma (UM). Both cancer types derive from melanocytes that share the same embryonic …