The extracellular matrix and the immune system: A mutually dependent relationship

TE Sutherland, DP Dyer, JE Allen - Science, 2023 - science.org
For decades, immunologists have studied the role of circulating immune cells in host
protection, with a more recent appreciation of immune cells resident within the tissue …

Synovial inflammation in osteoarthritis progression

E Sanchez-Lopez, R Coras, A Torres… - Nature Reviews …, 2022 - nature.com
Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …

The role of M1/M2 macrophage polarization in rheumatoid arthritis synovitis

M Cutolo, R Campitiello, E Gotelli… - Frontiers in …, 2022 - frontiersin.org
Innate and adaptive immunity represent a harmonic counterbalanced system involved in the
induction, progression, and possibly resolution of the inflammatory reaction that characterize …

Immunology of human fibrosis

M Bhattacharya, P Ramachandran - Nature Immunology, 2023 - nature.com
Fibrosis, defined by the excess deposition of structural and matricellular proteins in the
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …

Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis

L Wang, C He - Frontiers in immunology, 2022 - frontiersin.org
Macrophages are the most abundant immune cells within the synovial joints, and also the
main innate immune effector cells triggering the initial inflammatory responses in the …

The role of collagen in cancer: from bench to bedside

S Xu, H Xu, W Wang, S Li, H Li, T Li, W Zhang… - Journal of translational …, 2019 - Springer
Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Macrophage phenotypes in tissue repair and the foreign body response: Implications for biomaterial-based regenerative medicine strategies

KE Martin, AJ García - Acta biomaterialia, 2021 - Elsevier
Macrophages are a highly heterogeneous and plastic population of cells that are crucial for
tissue repair and regeneration. This has made macrophages a particularly attractive target …

Adipose tissue fibrosis in obesity: etiology and challenges

G Marcelin, EL Gautier, K Clément - Annual review of physiology, 2022 - annualreviews.org
Obesity is a chronic and progressive process affecting whole-body energy balance and is
associated with comorbidity development. In addition to increased fat mass, obesity induces …

Pro-regenerative biomaterials recruit immunoregulatory dendritic cells after traumatic injury

R Lokwani, A Josyula, TB Ngo, S DeStefano, D Fertil… - Nature Materials, 2024 - nature.com
During wound healing and surgical implantation, the body establishes a delicate balance
between immune activation to fight off infection and clear debris and immune tolerance to …

Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases

B Hinz, D Lagares - Nature Reviews Rheumatology, 2020 - nature.com
Organ fibrosis is a lethal outcome of autoimmune rheumatic diseases such as systemic
sclerosis. Myofibroblasts are scar-forming cells that are ultimately responsible for the …