Schizophrenia remains a challenging disease to treat effectively with current antipsychotic
medications due to their limited efficacy across the entire spectrum of core symptoms as well …

Schizophrenia is a severe psychiatric illness affecting almost 25 million people worldwide
and is conceptualized as a disorder of synaptic plasticity and brain connectivity …

Excess body weight is one of the most common physical health problems among patients
with schizophrenia that increases the risk for many medical problems, including type 2 …

Schizophrenia, a severe brain disorder that involves hallucinations, disordered thinking and
deficiencies in cognition, has been studied for decades in order to determine the early …

A series of new pyridobenzoxazepine derivatives with various heterocyclic amine side
chains were synthesized to explore two main parameters related to the distal basic nitrogen …

Rationale The second generation antipsychotic drug clozapine is a psychotherapeutic agent
with superior efficacy for treatment-resistant schizophrenia. Clozapine is associated with a …

Clozapine (CLZ) demonstrates a unique clinical efficacy relative to other antipsychotic
drugs. Previous work has linked the plasma ratio of CLZ and its major metabolite, N …

Background Drug discrimination is an increasingly valuable behavioral assay for the
preclinical development of antipsychotic drugs. The majority of studies have used the …

To the Editors: Cognitive dysfunction is a hallmark fea-ture of schizophrenia, often
presenting in patients with psychotic disorders since the first episode1 or earlier. 2 …

N-desmethylclozapine (NDMC) is the major active metabolite of the atypical antipsychotic
drug clozapine and may contribute to the therapeutic efficacy of clozapine. Although they …