Significance: The molecular machinery regulating autophagy has started becoming
elucidated, and a number of studies have undertaken the task to determine the role of …

Autophagy is the primary catabolic program of the cell that promotes survival in response to
metabolic stress. It is tightly regulated by a suite of kinases responsive to nutrient status …

Cadmium (Cd) is a known nephrotoxic heavy metal and proximal tubules are the major
target of Cd-induced acute kidney injury (AKI). We previously demonstrated that lysosomal …

BACKGROUND & AIMS: Metabolic stress during liver injury enhances autophagy and
provokes stellate cell activation, with secretion of scar matrix. Conditions that augment …

Liver ischemia‐reperfusion (I‐R) injury occurs during liver resection, liver transplantation,
and hemorrhagic shock. The main mode of liver cell death after warm and/or cold liver I‐R is …

Background The recurrence of hepatocellular carcinoma (HCC) after radiofrequency
ablation (RFA) remains a major clinical problem. Cells that survive the sublethal heat stress …

Background Normothermic machine perfusion of the liver (NMP-L) is a novel technique that
preserves liver grafts under near-physiological conditions while maintaining their normal …

Abstract Aflatoxin B1 (AFB1) is a potent hepatocarcinogen in humans and exposure to AFB1
is known to cause both acute and chronic hepatocellular injury. As the liver is known to be …

Endometriosis is a benign gynaecological disease which shares some characteristics with
malignancy like migration and invasion. It has been reported that both Hypoxia-Inducible …

Daphnetin (Daph), a natural coumarin derivative isolated from plants of the Genus Daphne,
possesses abundant biological activities, such as anti-inflammatory, antioxidant and …