Sources of DNA double-strand breaks and models of recombinational DNA repair
A Mehta, JE Haber - Cold Spring Harbor perspectives in …, 2014 - cshperspectives.cshlp.org
DNA is subject to many endogenous and exogenous insults that impair DNA replication and
proper chromosome segregation. DNA double-strand breaks (DSBs) are one of the most …
proper chromosome segregation. DNA double-strand breaks (DSBs) are one of the most …
Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae
LS Symington, R Rothstein, M Lisby - Genetics, 2014 - academic.oup.com
Homology-dependent exchange of genetic information between DNA molecules has a
profound impact on the maintenance of genome integrity by facilitating error-free DNA …
profound impact on the maintenance of genome integrity by facilitating error-free DNA …
DNA double-strand-break repair in higher eukaryotes and its role in genomic instability and cancer: Cell cycle and proliferation-dependent regulation
E Mladenov, S Magin, A Soni, G Iliakis - Seminars in cancer biology, 2016 - Elsevier
Eukaryotic cells respond to DNA damage by activating a comprehensive network of
biochemical pathways that enable damage recognition and initiate responses leading to …
biochemical pathways that enable damage recognition and initiate responses leading to …
End-joining, translocations and cancer
SF Bunting, A Nussenzweig - Nature Reviews Cancer, 2013 - nature.com
Fusion genes that are caused by chromosome translocations have been recognized for
several decades as drivers of deregulated cell growth in certain types of cancer. In recent …
several decades as drivers of deregulated cell growth in certain types of cancer. In recent …
Eukaryotic DNA polymerases in homologous recombination
M McVey, VY Khodaverdian, D Meyer… - Annual review of …, 2016 - annualreviews.org
Homologous recombination (HR) is a central process to ensure genomic stability in somatic
cells and during meiosis. HR-associated DNA synthesis determines in large part the fidelity …
cells and during meiosis. HR-associated DNA synthesis determines in large part the fidelity …
Break-induced replication occurs by conservative DNA synthesis
RA Donnianni, LS Symington - Proceedings of the National …, 2013 - National Acad Sciences
Break-induced replication (BIR) refers to recombination-dependent DNA synthesis initiated
from one end of a DNA double-strand break and can extend for more than 100 kb. BIR …
from one end of a DNA double-strand break and can extend for more than 100 kb. BIR …
Is homologous recombination really an error-free process?
J Guirouilh-Barbat, S Lambert, P Bertrand… - Frontiers in …, 2014 - frontiersin.org
Homologous recombination (HR) is an evolutionarily conserved process that plays a pivotal
role in the equilibrium between genetic stability and diversity. HR is commonly considered to …
role in the equilibrium between genetic stability and diversity. HR is commonly considered to …
Dynamic processing of displacement loops during recombinational DNA repair
Displacement loops (D-loops) are pivotal intermediates of homologous recombination (HR),
a universal DNA double strand break (DSB) repair pathway. We developed a versatile assay …
a universal DNA double strand break (DSB) repair pathway. We developed a versatile assay …
Multi-invasions are recombination byproducts that induce chromosomal rearrangements
Inaccurate repair of broken chromosomes generates structural variants that can fuel
evolution and inflict pathology. We describe a novel rearrangement mechanism in which …
evolution and inflict pathology. We describe a novel rearrangement mechanism in which …
Chromosome rearrangements via template switching between diverged repeated sequences
RP Anand, O Tsaponina, PW Greenwell… - Genes & …, 2014 - genesdev.cshlp.org
Recent high-resolution genome analyses of cancer and other diseases have revealed the
occurrence of microhomology-mediated chromosome rearrangements and copy number …
occurrence of microhomology-mediated chromosome rearrangements and copy number …