CDC6 as a Key Inhibitory Regulator of CDK1 Activation Dynamics and the Timing of Mitotic Entry and Progression
M El Dika, D Dudka, M Kloc, JZ Kubiak - Biology, 2023 - mdpi.com
Simple Summary The kinetics of Cyclin Dependent Kinase 1 (CDK1) activation must be
strictly controlled to guarantee a timely and physiological entry into mitosis. CDC6, a known …
strictly controlled to guarantee a timely and physiological entry into mitosis. CDC6, a known …
Dephosphorylation of the pre-initiation complex is critical for origin firing
In eukaryotes, cyclin-dependent kinase (CDK) ensures that the genome is duplicated exactly
once by inhibiting helicase loading factors before activating origin firing. CDK activates …
once by inhibiting helicase loading factors before activating origin firing. CDK activates …
The budding yeast GSK-3 homologue Mck1 is an essential component of the spindle position checkpoint
S Rathi, I Polat, G Pereira - Open Biology, 2022 - royalsocietypublishing.org
The spindle position checkpoint (SPOC) is a mitotic surveillance mechanism in
Saccharomyces cerevisiae that prevents cells from completing mitosis in response to …
Saccharomyces cerevisiae that prevents cells from completing mitosis in response to …
[HTML][HTML] Roles of phosphatases in eukaryotic DNA replication initiation control
F Jenkinson, P Zegerman - DNA repair, 2022 - Elsevier
In eukaryotes, the phosphorylation of replication initiation factors by protein kinases is
crucial to DNA replication control. This control ensures that the genome is only copied once …
crucial to DNA replication control. This control ensures that the genome is only copied once …
Proteome-wide forced interactions reveal a functional map of cell-cycle phospho-regulation in S. cerevisiae
Dynamic protein phosphorylation and dephosphorylation play an essential role in cell cycle
progression. Kinases and phosphatases are generally highly conserved across eukaryotes …
progression. Kinases and phosphatases are generally highly conserved across eukaryotes …
CDC6 as A Key Inhibitory Regulator of CDK1 Activation Dynamics and The Timing of Mitotic Entry and Progression
EL Mohammed, D Dudka, K Malgorzata, JZ Kubiak - 2023 - preprints.org
Timely mitosis is critically important for the early embryo development. It is regulated by the
activity of the ubiquitously conserved CDK1 kinase. The dynamics of CDK1 activation must …
activity of the ubiquitously conserved CDK1 kinase. The dynamics of CDK1 activation must …
Molecular characterisation of Mck1, a novel Spindle Position Checkpoint (SPOC) protein and mitotic inhibitor.
S Maniyar - 2022 - archiv.ub.uni-heidelberg.de
In Saccharomyces cerevisiae, the position of the mitotic spindle is surveyed by the spindle
position checkpoint (SPOC). SPOC ensures that cells do not exit mitosis if their anaphase …
position checkpoint (SPOC). SPOC ensures that cells do not exit mitosis if their anaphase …