The LDLR family of proteins is involved in lipoproteins trafficking. While the role of LDLR in
cardiovascular disease has been widely studied, only recently the role of other members of …

Statins are the gold-standard treatment for the prevention of primary and secondary
cardiovascular disease, which is the leading cause of mortality worldwide. Despite the safety …

Low-density lipoprotein-related receptors 5 and 6 (LRP5/6) are highly homologous proteins
with key functions in canonical Wnt signaling. Alterations in the genes encoding these …

Cardiovascular disease (CVD) and cancer are leading causes of mortality and morbidity
worldwide. Strategies to improve their treatment and prevention are global priorities and …

Genome-wide association studies (GWAS) have identified a genetic variant at a locus on
chromosome 1p13 that is associated with reduced risk of myocardial infarction, reduced …

The Wnt coreceptors Lrp5 and Lrp6 are essential for normal postnatal bone accrual and
osteoblast function. In this study, we identify a previously unrecognized skeletal function …

Components of the Wnt signaling cascade represent novel targets for pharmacological
intervention in cardiometabolic disease. Conversely, strategies targeting the Wnt signaling …

The underlying molecular genetic basis of combined hyperlipidemia, the most common
atherogenic lipid disorder, is poorly characterized. Rare, nonconservative mutations in the …

Cholesterol synthesis occurs in almost all cells, but mainly in hepatocytes in the liver.
Cholesterol is garnering increasing attention for its central role in various metabolic …

Wnt signaling plays crucial roles in development and tissue homeostasis, and its
dysregulation leads to various diseases, notably cancer. Wnt/β-catenin signaling is initiated …