Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and …
JS Helm, RA Rudel - Archives of toxicology, 2020 - Springer
Abstract Knowledge about established breast carcinogens can support improved and
modernized toxicological testing methods by identifying key mechanistic events. Ionizing …
modernized toxicological testing methods by identifying key mechanistic events. Ionizing …
Evaluating the mechanistic evidence and key data gaps in assessing the potential carcinogenicity of carbon nanotubes and nanofibers in humans
ED Kuempel, MC Jaurand, P Møller… - Critical reviews in …, 2017 - Taylor & Francis
In an evaluation of carbon nanotubes (CNTs) for the IARC Monograph 111, the Mechanisms
Subgroup was tasked with assessing the strength of evidence on the potential …
Subgroup was tasked with assessing the strength of evidence on the potential …
Quantitative interpretation of genetic toxicity dose‐response data for risk assessment and regulatory decision‐making: current status and emerging priorities
PA White, AS Long, GE Johnson - Environmental and Molecular …, 2020 - Wiley Online Library
The screen‐and‐bin approach for interpretation of genotoxicity data is predicated on three
false assumptions: that genotoxicants are rare, that genotoxicity dose–response functions do …
false assumptions: that genotoxicants are rare, that genotoxicity dose–response functions do …
Introduction to the use of linear and nonlinear regression analysis in quantitative biological assays
SW Jarantow, ED Pisors, ML Chiu - Current Protocols, 2023 - Wiley Online Library
Biological assays are essential tools in biomedical and pharmaceutical research. In simplest
terms, such an assay is an analytical method used to measure or predict a response in a …
terms, such an assay is an analytical method used to measure or predict a response in a …
[HTML][HTML] Evaluation of the genotoxic potential of acrylamide: Arguments for the derivation of a tolerable daily intake (TDI value)
S Guth, M Baum, AT Cartus, P Diel, KH Engel… - Food and Chemical …, 2023 - Elsevier
This opinion of the Senate Commission on Food Safety (SKLM) of the German Research
Foundation (Deutsche Forschungsgemeinschaft, DFG) presents arguments for an updated …
Foundation (Deutsche Forschungsgemeinschaft, DFG) presents arguments for an updated …
Nanomaterial genotoxicity evaluation using the high-throughput p53-binding protein 1 (53BP1) assay
M Fontaine, E Bartolami, M Prono, D Béal, M Blosi… - Plos one, 2023 - journals.plos.org
Toxicity evaluation of engineered nanomaterials is challenging due to the ever increasing
number of materials and because nanomaterials (NMs) frequently interfere with commonly …
number of materials and because nanomaterials (NMs) frequently interfere with commonly …
[HTML][HTML] Epigenetic repression of miR-17 contributed to di (2-ethylhexyl) phthalate-triggered insulin resistance by targeting Keap1-Nrf2/miR-200a axis in skeletal …
J Wei, Q Hao, C Chen, J Li, X Han, Z Lei, T Wang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Skeletal muscle insulin resistance is detectable before type 2 diabetes is
diagnosed. Exposure to di (2-ethylhexyl) phthalate (DEHP), a typical environmental …
diagnosed. Exposure to di (2-ethylhexyl) phthalate (DEHP), a typical environmental …
Application of the adverse outcome pathway framework to genotoxic modes of action
JC Sasaki, A Allemang, SM Bryce… - Environmental and …, 2020 - Wiley Online Library
In May 2017, the Health and Environmental Sciences Institute's Genetic Toxicology
Technical Committee hosted a workshop to discuss whether mode of action (MOA) …
Technical Committee hosted a workshop to discuss whether mode of action (MOA) …
DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis
J Fahrer, J Frisch, G Nagel, A Kraus, B Dörsam… - …, 2015 - academic.oup.com
Epidemiological studies indicate that N-nitroso compounds (NOC) are causally linked to
colorectal cancer (CRC). NOC induce DNA alkylations, including O 6-methylguanine (O 6 …
colorectal cancer (CRC). NOC induce DNA alkylations, including O 6-methylguanine (O 6 …
Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents
J Klapacz, LH Pottenger, BP Engelward… - … Research/Reviews in …, 2016 - Elsevier
From a risk assessment perspective, DNA-reactive agents are conventionally assumed to
have genotoxic risks at all exposure levels, thus applying a linear extrapolation for low-dose …
have genotoxic risks at all exposure levels, thus applying a linear extrapolation for low-dose …