The development of a vaccine against meningococcus B using reverse vaccinology

V Masignani, M Pizza, ER Moxon - Frontiers in immunology, 2019 - frontiersin.org
The discovery of vaccine antigens through whole genome sequencing (WGS) contrasts with
the classical hypothesis-driven laboratory-based analysis of microbes to identify …

A multi-component meningococcal serogroup B vaccine (4CMenB): the clinical development program

M O'Ryan, J Stoddard, D Toneatto, J Wassil, PM Dull - Drugs, 2014 - Springer
Recently approved in Europe and Australia, the multi-component meningococcal B vaccine,
4CMenB (Bexsero®, Novartis Vaccines and Diagnostics), contains three surface-exposed …

[HTML][HTML] Effectiveness of a meningococcal group B vaccine (4CMenB) in children

J Castilla, M García Cenoz, R Abad… - … England Journal of …, 2023 - Mass Medical Soc
Abstract Background In September 2015, the four-component, protein-based meningococcal
serogroup B vaccine (4CMenB; Bexsero) became available for private purchase in Spain …

Vaccination of infants with meningococcal group B vaccine (4CMenB) in England

SN Ladhani, N Andrews, SR Parikh… - … England Journal of …, 2020 - Mass Medical Soc
Abstract Background In September 2015, the United Kingdom introduced the
multicomponent meningococcal group B vaccine (4CMenB, Bexsero) into its publicly funded …

Effectiveness and impact of a reduced infant schedule of 4CMenB vaccine against group B meningococcal disease in England: a national observational cohort study

SR Parikh, NJ Andrews, K Beebeejaun, H Campbell… - The Lancet, 2016 - thelancet.com
Summary Background In September, 2015, the UK became the first country to introduce the
multicomponent group B meningococcal (MenB) vaccine (4CMenB, Bexsero) into a publicly …

[HTML][HTML] Detection of mcr-1 encoding plasmid-mediated colistin-resistant Escherichia coli isolates from human bloodstream infection and imported chicken meat …

H Hasman, AM Hammerum, F Hansen… - …, 2015 - eurosurveillance.org
The plasmid-mediated colistin resistance gene, mcr-1, was detected in an Escherichia coli
isolate from a Danish patient with bloodstream infection and in five E. coli isolates from …

[HTML][HTML] The epidemiology of invasive meningococcal disease in EU/EEA countries, 2004–2014

R Whittaker, JG Dias, M Ramliden, C Ködmön… - Vaccine, 2017 - Elsevier
Background Invasive meningococcal disease (IMD) is a major cause of bacterial meningitis
and septicaemia although infection by some serogroups may be prevented through …

Immunogenicity and safety of an investigational multicomponent, recombinant, meningococcal serogroup B vaccine (4CMenB) administered concomitantly with …

T Vesikari, S Esposito, R Prymula, E Ypma, I Kohl… - The Lancet, 2013 - thelancet.com
Background Meningococcal serogroup B disease disproportionately affects infants. We
assessed lot-to-lot consistency, safety and immunogenicity, and the effect of concomitant …

Meningococcal B vaccine (4CMenB): the journey from research to real world experience

R Rappuoli, M Pizza, V Masignani… - Expert Review of …, 2018 - Taylor & Francis
Introduction: Neisseria meningitidis serogroup B (MenB) is the most common cause of
bacterial meningitis in many industrialized countries and occurs at any age. The highest …

[HTML][HTML] Bactericidal antibody against a representative epidemiological meningococcal serogroup B panel confirms that MATS underestimates 4CMenB vaccine strain …

G Frosi, A Biolchi, ML Sapio, F Rigat, S Gilchrist… - Vaccine, 2013 - Elsevier
Abstract Background 4CMenB (Bexsero), a vaccine developed against invasive
meningococcal disease caused by capsular group B strains (MenB), was recently licensed …