Oral delivery of anticancer drugs: challenges and opportunities
The present report focuses on the various aspects of oral delivery of anticancer drugs. The
significance of oral delivery in cancer therapeutics has been highlighted which principally …
significance of oral delivery in cancer therapeutics has been highlighted which principally …
Recent advances in doxorubicin formulation to enhance pharmacokinetics and tumor targeting
J Lee, MK Choi, IS Song - Pharmaceuticals, 2023 - mdpi.com
Doxorubicin (DOX), a widely used drug in cancer chemotherapy, induces cell death via
multiple intracellular interactions, generating reactive oxygen species and DNA-adducted …
multiple intracellular interactions, generating reactive oxygen species and DNA-adducted …
Co-encapsulation of tamoxifen and quercetin in polymeric nanoparticles: implications on oral bioavailability, antitumor efficacy, and drug-induced toxicity
The present investigation reports the preparation, optimization, and characterization of orally
administrable PLGA-NPs co-encapsulated with tamoxifen (Tmx) and quercetin (QT). The …
administrable PLGA-NPs co-encapsulated with tamoxifen (Tmx) and quercetin (QT). The …
Recent advances in drug delivery nanocarriers incorporated in temperature-sensitive Pluronic F-127–A critical review
New polymeric systems are constantly developed for novel biomedical applications.
Pluronic F127 (PF127) is a tri-block copolymer with surface-active properties. It comprises a …
Pluronic F127 (PF127) is a tri-block copolymer with surface-active properties. It comprises a …
HSA coated iron oxide nanoparticles as drug delivery vehicles for cancer therapy
An ongoing effort in the field of nanomedicine is to develop nanoplatforms with both imaging
and therapeutic functions, the “nanotheranostics”. We have previously developed a human …
and therapeutic functions, the “nanotheranostics”. We have previously developed a human …
Targeted therapy of breast tumor by PLGA-based nanostructures: The versatile function in doxorubicin delivery
TS Dongsar, TT Dongsar, N Molugulu… - Environmental …, 2023 - Elsevier
Breast carcinoma is a molecularly diverse illness, and it is among the most prominent and
often reported malignancies in female across the globe. Surgical intervention …
often reported malignancies in female across the globe. Surgical intervention …
Nanostructured lipid carriers for oral bioavailability enhancement of exemestane: formulation design, in vitro, ex vivo, and in vivo studies
Exemestane (EXE) is a novel oral steroidal aromatase inhibitor approved for the treatment of
breast cancer. However, its oral clinical application is limited because of low aqueous …
breast cancer. However, its oral clinical application is limited because of low aqueous …
Improved stability and antidiabetic potential of insulin containing folic acid functionalized polymer stabilized multilayered liposomes following oral administration
The present study reports the folic acid (FA) functionalized insulin loaded stable liposomes
with improved bioavailability following oral administration. Liposomes were stabilized by …
with improved bioavailability following oral administration. Liposomes were stabilized by …
Folate-decorated PLGA nanoparticles as a rationally designed vehicle for the oral delivery of insulin
Aims: The present study reports a novel approach for enhancing the oral absorption and
hypoglycemic activity of insulin via encapsulation in folate-(FA) coupled polyethylene glycol …
hypoglycemic activity of insulin via encapsulation in folate-(FA) coupled polyethylene glycol …
Terminal modification of polymeric micelles with π-conjugated moieties for efficient anticancer drug delivery
Y Liang, X Deng, L Zhang, X Peng, W Gao, J Cao, Z Gu… - Biomaterials, 2015 - Elsevier
High drug loading content is the critical factor to polymeric micelles for efficient
chemotherapy. Small molecules of cinnamic acid, 7-carboxymethoxy coumarin and chrysin …
chemotherapy. Small molecules of cinnamic acid, 7-carboxymethoxy coumarin and chrysin …