Treating NASH by targeting peroxisome proliferator-activated receptors

B Staels, L Butruille, S Francque - Journal of Hepatology, 2023 - Elsevier
Abstract The pathophysiology of Non-Alcoholic Steatohepatitis (NASH) encompasses a
complex set of intra-and extrahepatic driving mechanisms, involving numerous metabolic …

Liver fat as risk factor of hepatic and cardiometabolic diseases

M Demir, SR Bornstein, CS Mantzoros… - Obesity …, 2023 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) is a disorder characterized by excessive
accumulation of fat in the liver that can progress to liver inflammation (non‐alcoholic …

EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD)

European Association for the Study of the Liver (EASL)… - Obesity Facts, 2024 - karger.com
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed non-
alcoholic fatty liver disease (NAFLD), is defined as steatotic liver disease (SLD) in the …

Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice

M Chen, JY Zhu, WJ Mu, HY Luo, Y Li, S Li… - Nature …, 2023 - nature.com
Exercise is an effective non-pharmacological strategy for ameliorating nonalcoholic fatty
liver disease (NAFLD), but the underlying mechanism needs further investigation. Cysteine …

Common and divergent molecular mechanisms of fasting and ketogenic diets

A Paoli, GM Tinsley, MP Mattson, I De Vivo… - Trends in Endocrinology …, 2024 - cell.com
Intermittent short-term fasting (ISTF) and ketogenic diets (KDs) exert overlapping but not
identical effects on cell metabolism, function, and resilience. Whereas health benefits of KD …

Intermittent fasting improves hepatic end points in nonalcoholic fatty liver disease: A systematic review and meta-analysis

M Lange, D Nadkarni, L Martin… - Hepatology …, 2023 - journals.lww.com
Methods: MEDLINE, EMBASE, Cochrane Central, and conference abstracts were searched
for IF interventions in adults with NAFLD until April 2, 2023. Meta-analysis with a random …

Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential

YL Xiao, Y Gong, YJ Qi, ZM Shao… - Signal Transduction and …, 2024 - nature.com
Diet, serving as a vital source of nutrients, exerts a profound influence on human health and
disease progression. Recently, dietary interventions have emerged as promising adjunctive …

Combined versus independent effects of exercise training and intermittent fasting on body composition and cardiometabolic health in adults: a systematic review and …

M Khalafi, ME Symonds, AH Maleki, MH Sakhaei… - Nutrition journal, 2024 - Springer
Introduction and aim Exercise training (Ex) and intermittent fasting (IF) are effective for
improving body composition and cardiometabolic health overweight and obese adults, but …

Postprandial exercise regulates tissue-specific triglyceride uptake through angiopoietin-like proteins

X Liu, Y Zhang, B Han, L Li, Y Li, Y Ma, S Kang, Q Li… - JCI insight, 2024 - insight.jci.org
Fuel substrate switching between carbohydrates and fat is essential for maintaining
metabolic homeostasis. During aerobic exercise, the predominant energy source gradually …

Exercise mitigates age-related metabolic diseases by improving mitochondrial dysfunction

D Jia, Z Tian, R Wang - Ageing Research Reviews, 2023 - Elsevier
The benefits of regular physical activity are related to delaying and reversing the onset of
ageing and age-related disorders, including cardiomyopathy, neurodegenerative diseases …