Glioblastoma multiforme (GBM) is a grade IV brain tumor characterized by a heterogeneous
population of cells that are highly infiltrative, angiogenic and resistant to chemotherapy. The …

Acquired resistance has curtailed cancer survival since the dawn of the chemotherapy age
more than half a century ago. Although the application of stem cell (SC) concepts to cancer …

Blood–brain/blood–tumor barriers (BBB and BTB) and interstitial transport may constitute
major obstacles to the transport of therapeutics in brain tumors. In this study, we examined …

Over the years, substantial evidence has definitively confirmed the existence of cancer stem-
like cells within tumors such as Glioblastoma (GBM). The importance of Glioblastoma stem …

Tumor dissemination and metastatic behavior account for the vast majority of cancer
associated mortality. Epithelial tumors achieve this progressive state via epithelial-to …

Advances in cancer research in the past have led to an evolving understanding of cancer
pathogenesis and the development of novel drugs that significantly improve patient …

Gliomas originate from glial cells and are the most frequent primary brain tumors. High-
grade gliomas occur∼ 4 times more frequently than low-grade gliomas, are highly …

Introduction Glioma is the most common primary brain tumor and is often associated with
treatment resistance and poor prognosis. Standard treatment typically involves radiotherapy …

Glioblastoma (GBM) is one of the most aggressive malignant tumors with an overall dismal
survival averaging one year despite multimodality therapeutic interventions including …

Background Glioblastoma multiforme (GBM) is a rapidly growing malignant brain tumor,
which has been reported to be organized in a hierarchical fashion with cancer stem cells …