MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

Extrachromosomal DNA (ecDNA) amplification is an important driver alteration in cancer. It
has been observed in most cancer types and is associated with worse patient outcome. The …

Oncogenes are commonly amplified on particles of extrachromosomal DNA (ecDNA) in
cancer,, but our understanding of the structure of ecDNA and its effect on gene regulation is …

The mechanisms behind the evolution of complex genomic amplifications in cancer have
remained largely unclear. Using whole-genome sequencing data of the pediatric tumor …

Acute myeloid leukemia (AML) is a malignant tumor of the immature myeloid hematopoietic
cells in the bone marrow (BM). It is a highly heterogeneous disease, with rising morbidity …

Numerous studies have shown that non-coding RNAs play crucial roles in the development
and progression of various tumor cells. Plasmacytoma variant translocation 1 (PVT1) mainly …

Extrachromosomal circular DNA (eccDNA), ranging in size from tens to millions of base
pairs, is independent of conventional chromosomes. Recently, eccDNAs have been …

Circular RNAs (circRNA) are RNA molecules built from fragments of linear pre-messenger
RNAs and other linear RNA species through a process termed “back-splicing” in which the …

Focal amplifications (FA) can mediate targeted therapy resistance in cancer. Understanding
the structure and dynamics of FAs is critical for designing treatments that overcome plasticity …

With covalently closed circular structures, circular RNAs (circRNAs) were once
misinterpreted as by-products of mRNA splicing. Being abundant, stable, highly conserved …