Multiple myeloma therapy: emerging trends and challenges

D Dima, D Jiang, DJ Singh, M Hasipek, HS Shah… - Cancers, 2022 - mdpi.com
Simple Summary Multiple myeloma (MM) is a frequent hematological malignancy
characterized by the uncontrolled growth of clonal plasma cells, primarily in the bone …

The role of bispecific antibodies in relapsed refractory multiple myeloma: a systematic review

R Khanam, OS Ashruf, SHB Waqar, Z Shah, S Batool… - Antibodies, 2023 - mdpi.com
Multiple myeloma is a heterogeneous clonal malignant plasma cell disorder, which remains
incurable despite the therapeutic armamentarium's evolution. Bispecific antibodies (BsAbs) …

The role of T cell immunity in monoclonal gammopathy and multiple myeloma: from immunopathogenesis to novel therapeutic approaches

I Lagreca, G Riva, V Nasillo, P Barozzi… - International Journal of …, 2022 - mdpi.com
Multiple Myeloma (MM) is a malignant growth of clonal plasma cells, typically arising from
asymptomatic precursor conditions, namely monoclonal gammopathy of undetermined …

Aberrant DNA methylation in multiple myeloma: A major obstacle or an opportunity?

C Muylaert, LA Van Hemelrijck, A Maes… - Frontiers in …, 2022 - frontiersin.org
Drug resistance (DR) of cancer cells leading to relapse is a huge problem nowadays to
achieve long-lasting cures for cancer patients. This also holds true for the incurable …

Anti-CD19/CD8 bispecific T cell engager for the potential treatment of B cell malignancies

N Maghsoodi, M Zareinejad, A Golestan… - Cellular …, 2023 - Elsevier
The administration of blinatumomab was accompanied by several adverse effects, including
activation of regulatory T-cells and cytokine storm. The objective of this study was to produce …

[HTML][HTML] Novel approaches to the treatment of multiple myeloma

KT Maples, SA Scott, S Lonial - Clin Adv Hematol …, 2023 - hematologyandoncology.net
The treatment landscape for multiple myeloma (MM) has evolved significantly over the last
decade with the approval of novel therapies and combinations in the newly diagnosed and …

Enabling the next steps in cancer immunotherapy: from antibody-based bispecifics to multispecifics, with an evolving role for bioconjugation chemistry

F Thoreau, V Chudasama - RSC Chemical Biology, 2022 - pubs.rsc.org
In the past two decades, immunotherapy has established itself as one of the leading
strategies for cancer treatment, as illustrated by the exponentially growing number of related …

Boosting immunity against multiple myeloma

R Lopes, BV Ferreira, J Caetano, F Barahona… - Cancers, 2021 - mdpi.com
Simple Summary Multiple myeloma is a hematological malignancy arising from the
proliferation of tumor antibody-producing cells in the bone marrow. In this cancer, tumor …

Clinical updates of B-cell maturation antigen-targeted therapy in multiple myeloma (MM) and relapsed/refractory MM

R Xing, M Wang, L Wang, M Pan… - International …, 2024 - spandidos-publications.com
Despite significant progress in managing multiple myeloma (MM) in recent years, certain
patients still have a short duration of therapeutic response, often relapsing within 18 months …

Therapeutic strategies to enhance immune response induced by multiple myeloma cells

Z Liu, C Yang, X Liu, X Xu, X Zhao, R Fu - Frontiers in Immunology, 2023 - frontiersin.org
Multiple myeloma (MM) as a haematological malignancy is still incurable. In addition to the
presence of somatic genetic mutations in myeloma patients, the presence of …