Proteoglycans (PGs) represent a large proportion of the components that constitute the
extracellular matrix (ECM). They are a diverse group of glycoproteins characterized by a …

Heparan Sulfate Proteoglycans (HSPGs) are important cell surface and Extracellular Matrix
(ECM) maestros involved in the orchestration of multiple cellular events in physiology and …

In the last few decades, heparan sulfate (HS) proteoglycans (HSPGs) have been an
intriguing subject of study for their complex structural characteristics, their finely regulated …

Mammalian glycosaminoglycans (GAGs), except hyaluronan (HA), are sulfated
polysaccharides that are covalently attached to core proteins to form proteoglycans (PGs) …

Cancer is an important cause of morbidity and mortality worldwide. Advances in research on
the biology of cancer revealed alterations in several key pathways underlying tumorigenesis …

Heparan sulfate (HS) is a glycosaminoglycan found mainly in its protein-conjugated form at
the cell surface and the extracellular matrix. Its high sulfation degree mediates functional …

Expression of the cell surface heparan sulfate proteoglycan syndecan-4 is dysregulated in
breast cancer, the most frequent malignancy in women. High expression of syndecan-4 …

Simple Summary Syndecans (SDCs; SDC1 to 4) are integral cell surface proteoglycans that
are expressed normally on various types of mammalian tissues. In cancer, SDCs' expression …

Exosomal microRNAs (miRNAs) from cancer cells play a key role in mediating the oral
squamous cell carcinoma (OSCC) microenvironment. The objective of this study was to …

Breast cancer continues to be a serious public health problem. The role of the hedgehog
pathway in normal development of the mammary gland as well as in carcinogenesis and …