The extracellular matrix as a multitasking player in disease

AD Theocharis, D Manou, NK Karamanos - The FEBS journal, 2019 - Wiley Online Library
Extracellular matrices (ECM s) are highly specialized and dynamic three‐dimensional (3D)
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …

The nature and biology of basement membranes

A Pozzi, PD Yurchenco, RV Iozzo - Matrix Biology, 2017 - Elsevier
Basement membranes are delicate, nanoscale and pliable sheets of extracellular matrices
that often act as linings or partitions in organisms. Previously considered as passive …

[HTML][HTML] Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

RV Iozzo, L Schaefer - Matrix biology, 2015 - Elsevier
We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …

Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics

NK Karamanos, Z Piperigkou, AD Theocharis… - Chemical …, 2018 - ACS Publications
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

Matrix modeling and remodeling: a biological interplay regulating tissue homeostasis and diseases

NK Karamanos, AD Theocharis, T Neill, RV Iozzo - Matrix Biology, 2019 - Elsevier
The overall structure and architecture of the extracellular matrix undergo dramatic alterations
in composition, form, and functionality over time. The stochasticity begins during …

Basement membranes: cell scaffoldings and signaling platforms

PD Yurchenco - Cold Spring Harbor perspectives in …, 2011 - cshperspectives.cshlp.org
Basement membranes are widely distributed extracellular matrices that coat the basal
aspect of epithelial and endothelial cells and surround muscle, fat, and Schwann cells …

Cancer metastasis: the role of the extracellular matrix and the heparan sulfate proteoglycan perlecan

Z Elgundi, M Papanicolaou, G Major, TR Cox… - Frontiers in …, 2020 - frontiersin.org
Cancer metastasis is the dissemination of tumor cells to new sites, resulting in the formation
of secondary tumors. This process is complex and is spatially and temporally regulated by …

The integrin–collagen connection–a glue for tissue repair?

C Zeltz, D Gullberg - Journal of cell science, 2016 - journals.biologists.com
ABSTRACT The α1β1, α2β1, α10β1 and α11β1 integrins constitute a subset of the integrin
family with affinity for GFOGER-like sequences in collagens. Integrins α1β1 and α2β1 were …

Proteoglycans in cancer biology, tumour microenvironment and angiogenesis

RV Iozzo, RD Sanderson - Journal of cellular and molecular …, 2011 - Wiley Online Library
Introduction• Perlecan: a pro‐angiogenic proteoglycan• Endorepellin, a C‐terminal fragment
of perlecan with anti‐angiogenic activity• Syndecans in cancer biology• Glypicans and the …

[HTML][HTML] Anticoagulant and signaling functions of antithrombin

AR Rezaie, H Giri - Journal of Thrombosis and Haemostasis, 2020 - Elsevier
Antithrombin (AT) is a major plasma glycoprotein of the serpin superfamily that regulates the
proteolytic activity of the procoagulant proteases of both intrinsic and extrinsic pathways …