PLGA/PLA-based long-acting injectable depot microspheres in clinical use: production and characterization overview for protein/peptide delivery

A Butreddy, RP Gaddam, N Kommineni… - International journal of …, 2021 - mdpi.com
Over the past few decades, long acting injectable (LAI) depots of polylactide-co-glycolide
(PLGA) or polylactic acid (PLA) based microspheres have been developed for controlled …

Long-acting PLGA microspheres: advances in excipient and product analysis toward improved product understanding

B Wan, Q Bao, D Burgess - Advanced drug delivery reviews, 2023 - Elsevier
Poly (lactic-co-glycolic acid)(PLGA) microspheres are a sustained-release drug delivery
system with several successful commercial products used for the treatment of a variety of …

FDA's poly (lactic-co-glycolic acid) research program and regulatory outcomes

Y Wang, B Qin, G Xia, SH Choi - The AAPS Journal, 2021 - Springer
Poly (lactic-co-glycolic acid)(PLGA) has been used in many long-acting drug formulations
which have been approved by the US Food and Drug Administration (FDA). However …

Poly (lactic-co-glycolic acid) microsphere production based on quality by design: a review

Y Hua, Y Su, H Zhang, N Liu, Z Wang, X Gao, J Gao… - Drug Delivery, 2021 - Taylor & Francis
Poly (lactic-co-glycolic acid)(PLGA) has garnered increasing attention as a candidate drug
delivery polymer owing to its favorable properties, including its excellent biocompatibility …

Challenges and Complications of Poly(lactic-co-glycolic acid)-Based Long-Acting Drug Product Development

YW Lim, WS Tan, KL Ho, AR Mariatulqabtiah… - Pharmaceutics, 2022 - mdpi.com
Poly (lactic-co-glycolic acid)(PLGA) is one of the preferred polymeric inactive ingredients for
long-acting parenteral drug products that are constituted of complex formulations. Despite …

Patient-centric long-acting injectable and implantable platforms─ an industrial perspective

S Alidori, R Subramanian, R Holm - Molecular pharmaceutics, 2024 - ACS Publications
The increasing focus on patient centricity in the pharmaceutical industry over the past
decade and the changing healthcare landscape, driven by factors such as increased access …

Recent progress in drug release testing methods of biopolymeric particulate system

Y Kim, EJ Park, TW Kim, DH Na - Pharmaceutics, 2021 - mdpi.com
Biopolymeric microparticles have been widely used for long-term release formulations of
short half-life chemicals or synthetic peptides. Characterization of the drug release from …

Quality by design thinking in the development of long-acting injectable PLGA/PLA-based microspheres for peptide and protein drug delivery

C Zhang, L Yang, F Wan, H Bera, D Cun… - International journal of …, 2020 - Elsevier
Abstract Adopting the Quality by Design (QbD) approach in the drug development process
has transformed from “nice-to-do” into a crucial and required part of the development …

Current state and opportunities with long-acting injectables: industry perspectives from the innovation and quality consortium “long-acting injectables” working group

A Bauer, P Berben, SS Chakravarthi… - Pharmaceutical …, 2023 - Springer
Long-acting injectable (LAI) formulations can provide several advantages over the more
traditional oral formulation as drug product opportunities. LAI formulations can achieve …

The effect of PLGA molecular weight differences on risperidone release from microspheres

M Kohno, JV Andhariya, B Wan, Q Bao… - International Journal of …, 2020 - Elsevier
The objective of the present study was to investigate the effect of molecular weight
differences of poly (lactic-co-glycolic acid)(PLGA) on the in vitro release profile of …